Neuro Flashcards
What does the diencephalon include?
Thalamus
Hypothalamus
What does the forebrain include?
Diencephalon
Cerebrum
Cerebral white matter tracts and the basal nuclei are involved in what?
Sensory and motor control.
Unilateral forebrain lesion can cause what type of limb deficits?
Contralateral due to crossing over nerves in the mibrain (pic)
Unilateral lesions in the pons and medulla will cause what type of limb deficit?
Ipsilateral
What cranial nerves extent from the pons and medulla?
3-12.
Where is the vestibular nuclei located?
Medulla
Flocculonodular lobe of the cerebellum
A decerebellate posture is seen in lesions where?
Rostral cerebellum
Signs of cerebellar disease?
Hypermetria
Intention tremors
Ataxia and wide based stance
Decerebellate posture.
In the spinal cord the gray matter contains what?
Interneurons and LMNs
The spinal cord give rise to a dorsal and ventral root. Which one is motor and which one is sensory?
Dorsal is sensory.
Ventral is motor.
Where is the cervical intumescenece?
C6-T2
Where is the lumbar intumescence?
L4-S3
Why do dogs with a cervical lesion have more pronounced UMN deficits in the rear limbs vs the forelimbs?
The rear limb tracts are more peripherally in the cord
What makes up the peripheral nerves?
12 CNs
36 pair spinal nerves
Explain the neuromuscular junction process?
Calcium dependent release of the neurotransmitter acetylcholine from the synaptic cleft
ACh diffuses across the synaptic cleft and binds to ACh muscle receptors
ACh is rapidedly removed by Acetylcholinesterase
Myasthenia gravis is what type of neuromuscular disorder?
Post synaptic
Reduction of the number of functional ACh receptors.
Presynatic neuromuscular disorders usually cause what clinical sign?
Flaccid tetraparesis
Decreased Spinal reflexes.
What are common clinical signs of muscle disorders?
Weakness
Stiff or stilted gait
Exercise intolerance
Where does the pelvic nerve originate from?
L5-L6
What does the pelvic nerve do during micturition?
Detects bladder fullness
Supplies PARAsympathetic innervation to the bladder - CAUSING DETRUSOR MUSCLE TO CONTRACT
What nerve controls the external urethral sphincter m allowing for conscious and reflex control?
Pudendal n.
The hypogastric n supplies what?
SYMPATHETIC tone causing detrusor muscle relaxation and contraction of the internal urethral sphicter.
What three nerves control micurition?
Pelvic - Parasympathetic
Pudendal - Somatic
Hypogastric - Sympathetic
Where does the hypogastric n arise from
Cranial to mid lumbar
What is a LMN bladder?
Injury to the sacral spinal cord (pelvic and pudendal n) causing a large, flaccid bladder that is easily expressed
What is an UMN bladder?
Spinal cord injury causing an enlarged bladder that is hard to express
What is reflex or automatic bladder?
5-10 days after acute UMN spinal cord injury, there might be reflex detrusor contraction causing spontaneous partial empyting.
What is detruser-urethral dyssynergia?
When there is a spinal lesion cranial to L5 causing diministed voluntary control and reflex hyperexcitability of the urethral sphincter. Causing involuntary contraction of the urtheral sphincter during detrusor contractions.
What is the difference between decerebrate and decerebellate rigidity?
Decerebrate - All four limbs are extended with an extended neck (MIDBRAIN LESION)
Decerebellate - Thoracic limbs are extended along with neck. Hips are flexed due to flexed iliopsoas. (ROSTRAL CEREBELLAR).
Patellar reflex contains what n?
Femoral nerve
Spinal nerve L4, L5, L^
Pelvic limb withdrawal contains what nerves?
Sensory - Sciatic n (tibia and peroneal on the lateral), Femoral (saphenous on the medial)
Motor - Sciatic n (tibia (flexion of the digits) and peroneal (flexion of the tarsus)).
What is the perineal reflex or bulbourethral reflex used to assess?
Pudendal n
S1-S3
Where does the lateral thoracic nerve come from and what does it do?
Lateral thoracic comes from C8-T1
What is in control of pupil constriction?
CN3 Occulomotor
Complete external ophthalmoplegia is usually caused by?
Cavernous sinus syndrome
What type of strabimus is caused by CN3 damage?
Ventrolateral strabimus
What type of strabimus is caused by CN4 damage?
Dorsolateral strabismus
What does CN5 (trigeminal n) innervate?
Sensory of the face, cornea, nasal septum, nasopharyngeal membrane, teeth and gingiva
Motor of the muscles of mastication.
Bilateral CN5 lesions cause?
Drop jaw and inability to close mouth.
CN7 innervates what?
Muscles of the face
Seory of the rostral two thirds of the tongue and palate
Lacrimal glands and mandibular and sublingual salivary glands
CN9 innervates what?
motor to the pharynx and palate
Sensory to the caudal third of the tongue and pharynx
Parasympathetic to the parotid and zygomatic salivary glands
Vagus innervates?
Motor and sensory to the larynx, pharynx and esophagus
How to test the parasympathetic portion of the vagus?
Push on the eyballs and see the bradycardia reflex
Differentials for peracute nerve dysfunction?
External trauma
Internal trauma (disc/fracture)
Hemorrhage
Infarct
Toxin
Differentials for subacute progressive nerve dysnfunction?
Infectious
Non-infectious
Rapidly growing tumors
Metabolic
Some toxins
SRMA commonly has elevated serum and CSF what?
IgA
Risk factors for seizures in a myelogram?
Dogs over 29kg
Cisternal myelography
Two or more injections of contrast.
What projections is the most benifical for describing where a lesion is on the myelogram?
Lateral… the VD says the same thing all the time.
What are the most commonly biopsied nerves?
Common peroneal nerve and the ulnar n.
Brainstem lesions commonly have these clinical signs?
Altered consciousness
CN deficity
UMN paresis
Ataxia
CP deficits
List some metabolic encephalopathies?
Hyperosmolality
Hepatic encephalopathy
Hypoglycemia
Uremia
Electrolyte distrubances.
CPs are usually what with cerebellar diseases?
Normal
Reasons for ischemic strokes/clots that may not be on your radar?
Septic foci (endocarditis)
Primary/metastatic neoplasia
Vasculitis
HW
Cardiac disease.
Hypothyrodism/DM/Cushings and hyperlipidemia
Hypertension
Most common infarct location in dogs? Cats?
Cerebellar/Forebrain - Dog
Forebrain/brainstem - Cat
Feline ischemic encephalopathy - what artery is most commonly affected?
Middle cerebral artery
Feline ischemic encephalopathy - what time of year and place is it most common?
Summer - NE USA and outdoors
What pathology besides edema is common with cuterebra migration?
Infarction
What percentage of congenital hydrocephalus do not have symptomes until 2 years of age?
30%
What dogs get lissencephaly?
Lhasa Apso
Wire Fox Terrier
Irish Setter
What is the most common non-infectious inflammatory brain disease in dogs?
Granulomatous meningoencephalitis (GME)
What is cerebellar abiotrophy?
Neurodegeneration of the cerebellum in young dog (2-12 months)
There is adult onset in some breeds.
What is a main differential for cerebellar abiotrophy?
Neosporosis due to atrophy of the cerebellum
What side effects are seen with KBr toxicity?
Dysphagia
Megaesophagus
Repetitive episodes of autonomic signs (vomiting, diarrhea, abdominal discomfort, repetitive swallowing, licking or eating grass) could be a sign of?
FOCAL AUTONOMIC SEIZURE DISORDER.
Sign of pheobarital responsive syndrome?
Drooling, reching, dysphagia, enlargement of the mandibular salivary glands with necrosis.
What percentage of dogs and cats have idiopathetic epilepsy?
25%-30% dogs
Rare in cats
What percentage of dogs and cats have intracranial causes?
35% - dogs
Most cats
What coomon toxins cause seizures?
Strychinine
Metaldehyde (slug/snail/rat posison)
Mycotoxins
Chlorinated hdrocarbons (insecticides)
Organophosphates/Carbamates (INsecticides)
Lead
Ethylene glycol
Scar tissue-related acquired epilepsy is seen as what on MRI?
Normal
What is pendular nystamus and who is it common in?
Oscillatory movement with no slow or fast phase
Siamese, Birman and himalayan cats due to congenital abnormalities
Physiologic nystagmus is controlled by what reflex?
Oculocephalic reflex
What signs are the most consistent with Central vestibular disease?
Vertical nystagmus
UMN limb deficits
What CNs can be affected if lesions are at the cerebellomedullary angle?
CN5, CN7 and CN8
What is paradoxical vestibular syndrome?
Where the lesion is in the caudal cerebellar peduncle or flocculonodular lobe of the cerebellum
Causes head tilt on the contral lateral side
CP deficits on the ipslateral side
What is the difference between geriatric canine vestibular disease and feline idiopathic vestibular syndrome?
Feline idiopathic happens at any age…mid-atlantic… summer time
Most common aural tumors?
SCC
Ceruminous gland adenoma/adenocarcinoma
sebaceous adenoma/adenocarcinoma
Lymphoma
CN8 = neurofibroma, neurofibrsarcoma.
Differentials for peripheral vestibular disease?
Otitis media
Old dog
Polyps
idiopathic
trauma
neoplastic
Aminoglycoside
Congenital (3 months or less)
Hypothyroidism.