Neoplasia Flashcards
What makes lymphoma different from leukemias?
Lymphoma originates from solid organs while leukemia orginates from bone marrow.
How many times more likely is a cat to get lymphoma that has FIV? FeLV and FIV?
FIV only = 6x
FIV and FeLV = 75x
What dog breeds commonly get B-Cell lymphoma?
Cockers and bassets
What dog breeds commonly get T-Cell lymphoma?
Boxers, Siberian huskies and shih tzus
Lymphoma has a what type of age distribution? Why ini cats is this thought to be?
Bimodal
Young cat = FeLV
Old cat = just normal Lymphoma
What are the four anatomic forms of lymphoma?
Multicentric - lymph nodes +/- spleen, liver, bone marrow
Mediastinal - Mediastinal lymph nodes +/- bone marrow
Alimentary - GI +/- intraabdominal lymphadenopathy
Extranodal - Renal, ocular, cutaneous
What anatomic form is most common in a dog? Cat?
Dog - Multicentric - 80% of cases
Cat - Alimentary - 70% of cases
Common first sign of lymphoma in dogs?
PU/PD - hypercalcemia. This is rare in cats
Most common extranodal lymphomas in dogs? Cats?
Dogs - cutaneous and ocular
Cats - nasopharyngeal, ocular, renal, neural
Donut shaped skin lesion consistent with?
Cutaneous lymphoma.
Most cats with cutaneous lymphoma do NOT have this?
FeLV …weird.
There is some reports of an association between what extranodal types of lymphoma in cats?
Neural and renal.
What are the three forms of CNS lymphoma?
Solitary epidural lymphoma
Neuropil (intracranial or intraspinal) lymphoma— Called TRUE CNS lymphoma
Peripheral nerve lymphoma.
Dogs with multicentric lymphoma commonly relapse into what?
CNS lymphoma.
What is the only clinically relevant paraneoplastic syndrom with lymphoma?
Hypercalcemia in dogs.
What paraneoplastic disease in dogs with lymphoma is rare in cats?
Hypercalcemia.
What does TNM mean?
Tumor, node, metastasis.. staging system
What are the stages of lymphoma (5)?
- Solitary lymph node involvement
- More than one lymph node on one side of the diaphragm
- Generalized lymph node involvement
- Stage 3 plus hepatomegaly or splenomegaly
- Bone marrow or extranodal involvement
- A = Asymptomatic
- B = Sick
What is the only prognostic indicator in the lymphoma staging scale in dogs?
Sick or not sick
What breed of dog commonly has T-Cell lymphoma?
Boxers
Hemangiosarcomas in dogs have a predilection for older dogs of what sex and breed (2)?
Males
German Shepherd
Goldens
Greyhounds commonly get HSA where?
Hind leg musle
What types of HSA are not aggressive?
Dermal and conjunctival.
Spindle cells are a sign of what type of neoplasia?
Sarcoma.
What is the probability of diagnosing HSA on cytology from effusion?
<25%
What is the big difference between cats and dogs with primary bone tumors?
Cats can be cured with wide surgical excision.
Canine OSA causes what in racing greyhounds vs show greyhounds?
Racing greyhounds: 25% of death
Show greyhounds: OSA is extremely rare.
Unique places for osteosarcoma in Great danes, Rotties and Greyhounds?
Great danes - distal radius
Rotties and Grey hounds - proximal femur
What is a negative prognostic indicator with OSA?
Lung mets
What breed is at high risk for MCT?
Brachiocephalic
Goldens
10-15% of MCT are indistinguishable from?
lipomas
What are the three categories of MCT?
Well differentiated - 1
Moderately differentiated - 2
Differentiated - 3
What type of metastasis is common with MCT?
Skip metastasis - every lymph node in the region should be aspirated.
What percentage of dogs with advanced MCT have gastroduodenal ulceration?
80%
What type of MCTs are seen in cats?
Visceral and cutaneous.
Multiple intestinal masses in cats are most commonly associated with?
Lymphoma and MCT (can coexist)
What is the biologic behavior of cutaneous mast cell in cats?
Benign
What type of tumor is injection site sarcomas normally?
Fibrosarcoma
What is the 3,2,1 rule for injection site tumor in cats?
- mass persists for more than 3 months
- mass is larger than 2cm
- mass grows 1 month after injection
How do injection site sarcomas (FSA) differ from regular FSA?
Injection site sarcomas (FSA) are much more aggressive.
