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BDS 1 BAMS > Nervous System > Flashcards

Nervous System Flashcards

1
Q

What are nissl bodies?

A

Large Rough ER, a lot of protein synthesis

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2
Q

Why are nerve cells incapable of regeneration?

A

They have no centrioles

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3
Q

What are ependymal cells?

A

Simple cuboidal ciliated epithelial cells. Line fluid filled ventricles and spinal cord, determines composition and helps move fluid along

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4
Q

What are astrocytes?

A

Star shaped cells surrounding blood vessels in brain and spinal cord. Any molecules passing from blood to brain must pass through this first, blood brain barrier

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5
Q

What are microglial cells?

A

From phagocytic lineage, clear up debris in CNS, either micro-organisms or dead nerve cells

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6
Q

What are oligodendrocytes?

A

They myelinate axons in the CNS, one of these can myelinate up to 50 axons

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7
Q

What are schwann cells?

A

Myelinate axons in the PNS, they wrap their membrane around the axons - if unmyelinated, only cytoplasm wrapped around for protection

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8
Q

What are satellite cells?

A

Flattened cells covering cell bodies to provide protection

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9
Q

How is the membrane potential maintained?

A

In two ways. Passive diffusion of K ions out of cell, these channels are always open so constant leakage of K from the cell. Also, the Na/K active transport, 3Na out of the cell, 2K into the cell, net loss of one +ve ion. So ICF is negative to ECF.

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10
Q

Describe 2 ways in which the membrane potential can be altered.

A

By excitatory post-synaptic potentials - depolarises the membrane, bringing it closer to threshold
By inhibitory post-synaptic potentials - hyperpolarises the membrane, moving it further from threshiold

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11
Q

What is the threshold of membrane potential for an AP?

A

-55mV

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12
Q

What occurs at -55mV?

A

voltage-gated Na channels open, causing the membrane to depolarise as there is an influx of Na ions

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13
Q

What occurs at +35mV?

A

voltage-gated Na channels are closed and voltage-gated K channels are opened - K leaves the cell, causing hyperpolarisation

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14
Q

How does local anaesthetic work?

A

Blocks Na channels, AP cannot be generated

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15
Q

How can an AP be propagated?

A

Along the membrane, from a positive part of the membrane to the adjacent negative part, can only travel in one direction due to refractory period

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16
Q

What is the refractory period?

A

When voltage-gated Na channels are inactivated so an AP cannot be generated

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17
Q

What increases the speed of an action potential?

A

The diameter of the axon and myelination

18
Q

How does myelination increase the speed of an AP?

A

It insulates the membrane so the ICF is not in contact with the ECF and there is no membrane potential. However, it leaves areas unmyelinated, so are exposed to ECF, thus can achieve an AP - node of ranvier. So the AP jumps from node to node

19
Q

What stimulates the synaptic vesicles to move to the membrane?

A

As AP arrives at the axon terminal, it stimulates the release of calcium, this then activates the vesicles

20
Q

How can a neurotransmitter be inactivated?

A

Enzymes breaking it down - e.g. acetylcholinerase or by re-uptake into pre-synaptic cleft

21
Q

How can the same neurotransmitter exert a different effect on the same cell?

A

By binding to different receptors, it stimulates different 2nd messenger systems, thus different response

22
Q

What is summation?

A

When several post-synaptic potentials act on the one cell at the same time, come together to generate a response - e.g. many required to reach threshold

23
Q

What neurotransmitter is released at the neuromuscular junction?

A

Acetylcholine

24
Q

Where does acetylcholine bind to on the muscle cell?

A

Sacrolemma - t-tubules

25
Q

How does botox work?

A

Blocks the release of acetylcholine at the NMJ, thus no contraction of muscle

26
Q

What is found in the grey matter of the spinal cord?

A

Cell bodies - of secondary afferent neurones, of motor neurones and terminal primary afferent neurones

27
Q

What is the dorsal root?

A

Where sensory afferent neurones enter the spinal cord

28
Q

What is the ventral root?

A

Where motor efferent neurones leave the spinal cord

29
Q

Why do certain segments of the spinal cord have more grey matter?

A

They receive more sensory input from visceral organs - e.g. lumbar and sacral segment

30
Q

Why do certain segments of the spinal cord have more white matter?

A

The cervical and thoracic segments have more white matter as axons from lower segments travelling up to the brain all combine, the tracts are bigger

31
Q

What makes up the forebrain?

A

Cerebrum and diencephalon - thalamus and hypothalamus

32
Q

What makes up the midbrain?

A

Reflexes for sight and hearing

33
Q

What makes up the hindbrain?

A

The brainstem - medulla oblongata, pons and cerebellum

34
Q

What cranial nerves are part of the parasympathetic NS?

A

CN III, VII, IX, X - oculomotor, facial, glossopharyngeal and vagus

35
Q

What neurotransmitter is used in sympathetic NS?

A

Acetylcholine used at ganglia - between pre and post, noradrenaline used at post to effector organ

36
Q

What neurotransmitter is used in parasympathetic NS?

A

Acetylcholine only

37
Q

What are the receptors that acetylcholine can exert it’s effect on?

A

Muscarinic and nicotinic

38
Q

What is the importance of propanol?

A

Agonist of acetylcholine at the M3 receptor in salivary glands, can stimulate salivation - important for those undergoing radiotherapy, reduce cell damage

39
Q

What receptors can noradrenaline from the sympathetic NS work on?

A

Beta receptors - relaxation in bronchioles (type 2) and in heart (1)
Alpha receptors - constriction in blood vessels smooth muscle

40
Q

Give an example of single control.

A

smooth muscle in blood vessels, only controlled by sympathetic, level of dilation is dependant on level of stimulation of sympathetic activity

BDS 1 BAMS (13 decks)

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