Nervous System 1 Flashcards
One of the two major control systems of the body mediating systemic homeostatic processesmuscle contractionintegration of blood oxygen, carbon dioxide, and pH levels via respiratory activityregulation of volumes and pressures in the circulation via cardiovascular and urinary functiondigestive system motility and secretion
Nervous System
______ system is a quick fix to homeostatic disturbance
Nervous system
____ system is slower long term maintenance
Endocrine system
What are the functional units of the nervous system?
Neurons
What are the support cells of neurons?
Neuroglia
Nervous system uses a combo of ____ and _____ to communicate info around body
chemical and electrical signals
_____ are stimulated by environmental changes or the activities of other cells
Dendrites
____ contains the nucleus and mitochondria, and other organelles and inclusions
Cell body
____ conducts nerve impulse toward synaptic terminals
Axon
_____ are clusters of ribosomes in cell body
Nissl Bodies
______ affect another neuron or effector organ
Synaptic terminals
_____ are clusters of myelin
Internodes
____ are formed by neuroglial cells
Internodes
____ form myelin for axons in CNS
Oligodendrocytes
____ form myelin for axons in PNS
Schwann cells
Internodes separated by small segments of axon not covered in myelin called ______Function: Speed up the rate of nerve impulse conduction (Saltatory conduction)
Nodes of Ranvier
(pseudounipolar neurons, bipolar)Afferent division of PNSCarry sensory information from reflex receptor to CNSDendrites/Cell body in PNSAxons typically myelinated and extend into CNS
Sensory Neurons
(Multipolar neurons)Efferent division of PNSCarry motor commands from CNS to EFFECTORSDendrites/Cell body in CNSAxons typically myelinated, extend into PNS and synapse with effectors
Motor Neurons
(Multipolar, Anaxonic)Found only in the CNSCarry information from one neuron to anotherIntegration
Interneurons
Always the same (depolarization followed by repolarization) with no change in strength or size as they travel along the membrane–All-or-none –Triggered at Axon Hillock when Threshold Potential reached (Vm at which AP triggered; typically around -50mV))–Always propagates along cell membrane of axon from axon hillock toward axon terminals –Relatively fast changes in Vm
Action potential
(Vm at which AP triggered; typically around -50mV))
Threshold Potential
–Small changes in membrane potential of variable strength/amplitude –Only travel a short distance along membrane and lose strength as they travel–Often last longer than APs; Ex. IPSP and EPSP
Graded Potentials (GP):
(depolarizations); moves Vm towards threshold potential; increases likelihood of AP
EPSPs. Excitatory postsynaptic potentials
(hyperpolarizations); moves Vm away from threshold; decreases likelihood of AP
IPSPs. Inhibitory postsynaptic potentials
Closed at resting Vm, quickly opens at threshold depolarization (Na+)
Voltage-gated Na channel Activation gate
Open at resting Vm, slowly closes at threshold depolarization (Na+)
Voltage-gated Na channel Inactivation gate
Single voltage gate begins to open at threshold, but is slow–delayed by the same time as the VG Na+ channel’s inactivation gate.
Voltage-gated K+ channel
Voltage-gated Na channel opens at _____
threshold membrane potential
Voltage-gated K channel opens at ______
peak of AP
During this time it is impossible for the cell to fire another action potential. Due to all-or-none activation & the voltage-gated Na+channels’ closed inactivation gates; can’t fire another AP during this point
Absolute Refractory Period
During this time a larger-than-normal EPSP can elicit an action potential. Due to: Some Na+ channels resetting to resting state After hyperpolarization; can fire another AP; resets Na channels
Relative Refractory Period
______ increases membrane excitability; ;depolarizes membrane potential moving closer to threshold
Hyperkalemia 3.5
_____ reduces membrane excitability; depolarizes membrane and cause inactivation of VG Na channels
Hyperkalemia >6Mm
_____ reduces membrane excitability; hyperpolarizes membrane further from threshold
Hypokalemia
____ binds to external surfaces of Na+ channel setting their excitable state
Calcium
Relating to Ca, ____ reduces membrane excitability
Hypercalcemia
Relating to Ca, ____ increases membrane excitability
Hypocalcemia
____ functions as an insulator on an axon; speeds up conduction velocity of AP; conserves axon energy; helps produce saltatory conduction
Myelin
What are the 2 factors that determine speed of an AP?
Axon diameter and myelin
____ is an autoimmune demyelination disease of the CNS
Guillain-Barre Syndrome
____ is an autoimmune demyelination disease of the PNS
Multiple Sclerosis