Nerve regeneration and Repair Flashcards
1
Q
Essential requirements needed for repair of a nerve injury
A
Survival of the nerve cell body
Clearance of the damaged distal axon, myelin breakdown products and other tissue debris
An environment that stimulates new axonal regrowth
Guidance cues for the axon to find its original cellular target
2
Q
Failure of CNS neurons to regenerate is due to
A
CSPGs in the glial star
Myelin debris
Expression of molecules- TNFs/FGFs/Lingo/Nogo
- all inhibitory on neuron-retract axons!
3
Q
In PNS Glial cells
A
Schwann cells- help clear debris
produce growth promoting molecules to guide axons
4
Q
In CNS glial cells
A
Astocytes- glial star
Oligodendrocyte- fail to help clear debris
5
Q
Chodroitinase ABC
A
Enzyme
- Removes inhibitory proteoglycans expressed in glial star
- creates env. for axonal growth
