Chronobiology Flashcards

1
Q

Wakefulness

A

High freq beta waves

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2
Q

Drowsy

A

Alpha waves

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3
Q

Stage 1

A

Theta waves

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4
Q

stage 2

A

sleep spindles and K complexes

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5
Q

Stage 3

A

delta waves

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6
Q

Stage 4

A

more delta waves

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7
Q

REM

A

fast waves with sawtooth waves

  • dreams occur
  • EEG appear awake
  • sympathetic tone dominates
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8
Q

6 transmitters keeping you awake

A
Ach
glu
ne
hist
serotonin
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9
Q

Ach

A

Released for Basal forebrain and Laterodorsal and pedunculopontine segmental nuclei

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10
Q

Basal forebrain

A

Releases Ach- during wakefulness and REM

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11
Q

Laterodorsal and pedunculopontine segmental nuclei

A

Release Ach- promotes wakefulness most robustly via projections to thalamus

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12
Q

NE

A

Released from Locus Coeruleus

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13
Q

Locus Coeruleus

A
releases NE- during wakefulness
some during NREM and NON during REM
-attention and task performance
-overfiring causes insomnia and anxiety
- has to have optimal release
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14
Q

Histamine

A

Released from tuberomammilary nucleus

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15
Q

Tuberomammilary nucleus

A

releases histamine

increased firing while awake>NREM>REM

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16
Q

Dopamine

A

Ventral periaqueductal gray

17
Q

vPAG

A

Dopamine- fires during wakefulness

-provide motivational arousal- keeps ppl awake

18
Q

Orexin/hypocretin

A

Excitatory neuroppeptides made in lateral hypothalamus

  • wakefulness regulators
  • fire only when awake
  • back up generator
19
Q

VLPO

A

off switch that uses GABA and Galanin transmitters to shut down wakefulness- fires while alseep

20
Q

MNPO

A

fires mostly while drifting off to sleep

21
Q

During REM sleep and NREM sleep

A

NREM- 5ht, ne, da all fire- suppress ach

REM- Ach fires and inhibits 5ht, ne, da

22
Q

Sublaterodorsal nucleus (SLD)

A

GABA neurons- firing during REM to inhibit motor tracts