nephritic syndrome Flashcards
what is nephritic syndrome?
a group of symptoms that occur with some disorders that cause swelling and inflammation of the glomeruli in the kidney
what are the types of causes of nephritic syndrome?
- systemic
- renal
- all examples of T3 hypersensitivity except good pastures ( T2)
what are the renal causes of nephritic syndrome?
- ig A nephropathy
what are the systemic causes of nephritic syndrome?
- SLE
- post strep glomerulonephritis
- good pastures
- small vessel vasculitis
how is nephritic syndrome diagnosed?
- kidney biopsy
- urinalysis
- bloods ( high ESR + CRP)
how is nephritic syndrome treated?
- BP control - Acei/ ARB
- corticosteroids - inflammation
what is IgA nephropathy?
- deposition of IgA into the mesangium of the kidney
what are the symptoms of IgA nephropathy?
-presents asymptomatically
-haematuria
what does IgA nephropathy cause?
- causes inflammation and damage
how is IgA nephropathy diagnosed?
- immunoflourescence microscopy –> IgA complex deposition
- Biopsy
what is the treatment for IgA nephropathy?
-non curative
-30% progress to ESRD ( End stage renal disease)
- BP control- Acei
- fish oil and steroids if persistent proteinuria
what is post strep glomerulonephritis?
- deposition of strep antigens ( group A, B) haemolytic strep ( s pygones) post infection ( 3-6 weeks)
what does post strep glomerulonephritis cause?
inflammation and damage
what are the symptoms of post strep glomerulonephritis
- visible haematuria
- acute nephritis
how is post strep glomerulonephritis diagnosed
- evidence of strep infection
- light microscope
- e microscope
- immunoflouresence