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Anatomical pathology > NEOPLASIA > Flashcards

NEOPLASIA Flashcards

1
Q

Define Neoplasia?

A

Slide 5

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2
Q

Define Neoplasm?

A

Slide 5

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3
Q

Persistent of tumor results from?

A

Slide 5

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4
Q

Differentiate between cancer and tumor

A

Slide 5

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5
Q

Tumors are clonal. Why?

A

Slide 6

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6
Q

Tumor depends on the host for?

A

Slide 6

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7
Q

Name and explain the Two basic components of tumors?

A

Slide 6

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8
Q

Name four basic components of tumors?

A

Slide 4

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9
Q

Differentiate between benign and malignant tumors

A

Slide 8

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10
Q

Define cell differentiation?

A

Slide 10

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11
Q

Define Anaplasia?

A

Slide 17
10

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12
Q

Define Parenchyma and Stroma?

A

Slide 6

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13
Q

Tumors can be differentiated on the basis of?

A

Slide 9

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14
Q

Define Dysplasia?

A

Slide 12

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15
Q

Define Dysplasia?

A

Slide 12

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16
Q

Define Local invasion and Metsastasis

A

Slide 15

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17
Q

Define Papillary Cystadenoma

A

Slide 29

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18
Q

Tumors arising from mesenchymal tissue are known as? give 2 examples?

A

Slide 30

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19
Q

Tumors that started from epithelial cell called? Give example

A

Slide 6

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20
Q

Define Adenocarcinoma?

A

Slide 32

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21
Q

What is a mixed tumor?

22
Q

Mixed tumors are monoclonal, what does this mean?

23
Q

Mixed tumour contains representative of a single germ layer, give examples of theses?

A

Pleomorphic adenoma
Slide 33

24
Q

Teratomas resemblance normal derivatives of?

A

More than one germ layer, arises from totipotent cells
Slide 33

25
Q

Define Harmatoma?

A

Malformation of a mass of disorganized but matured specialized cells or tissues indiginous to a particular
Site eg Odontoma
Slide 35

26
Q

Define Choristoma? Nomenclature of Misnormer

27
Q

List the role of factors that lead to the pathogenesis of neoplasm? [5]

28
Q

Most cancers are ———————– butsome are ———————-?[2]

A
  1. Sporadic (random, isolated, scattered)
  2. Familial
29
Q

What are the features that characterized familial cancers?

30
Q

Explain Genetic predisposition to cancer?

31
Q

Explain Age as a predisposing factor to developing CA?

32
Q

List CA that affects children? [6]

A

WRRONL
Slide 40

33
Q

How does the environment lead to development of carcinomas?

A

Slide 41-42

34
Q

Explain how acquired factors predispose people to Neoplasm?

35
Q

Explain the acquired predisposing factors to neoplasm?

36
Q

Define a precursor lesion

37
Q

Differentiate between precursor lesion and precursor condition table

38
Q

Deficiency of —————– increase risk of cancer?

A
  1. T-cell immunity
    Slide 44
39
Q

Discuss cellular and molecular Hallmarks of CAancer? [8]

40
Q

Define carcinogenic?

41
Q

Genetic change in carcinogenesis can be due? [3]

42
Q

Define genetic hypothesis?

43
Q

What are the targets for cancer causing mutations (regulatory) ?

A

Four classes
Slide 50

44
Q

Discuss Proto-oncogene?

45
Q

Explain the MoA of Proto-oncogene? [4]

46
Q

Anti cancer drugs target?

A

Oncogenes
Slide 52

47
Q

Genetic mechanisms associated with oncogene activation are? [4]

48
Q

What does tumo7r suppressor genes need?

A
  1. Both alleles to be damaged for transformation to occur
49
Q

Dicuse the function of Tumour suppressor genes?

50
Q

Etiology over cancer: carcinogenic agents? [3]

Anatomical pathology (9 decks)

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