NEOPLASIA

Question 1

Define Neoplasia?

Answer 1

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Question 2

Define Neoplasm?

Answer 2

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Question 3

Persistent of tumor results from?

Answer 3

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Question 4

Differentiate between cancer and tumor

Answer 4

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Question 5

Tumors are clonal. Why?

Answer 5

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Question 6

Tumor depends on the host for?

Answer 6

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Question 7

Name and explain the Two basic components of tumors?

Answer 7

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Question 8

Name four basic components of tumors?

Answer 8

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Question 9

Differentiate between benign and malignant tumors

Answer 9

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Question 10

Define cell differentiation?

Answer 10

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Question 11

Define Anaplasia?

Answer 11

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10

Question 12

Define Parenchyma and Stroma?

Answer 12

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Question 13

Tumors can be differentiated on the basis of?

Answer 13

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Question 14

Define Dysplasia?

Answer 14

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Question 15

Define Dysplasia?

Answer 15

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Question 16

Define Local invasion and Metsastasis

Answer 16

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Question 17

Define Papillary Cystadenoma

Answer 17

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Question 18

Tumors arising from mesenchymal tissue are known as? give 2 examples?

Answer 18

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Question 19

Tumors that started from epithelial cell called? Give example

Answer 19

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Question 20

Define Adenocarcinoma?

Answer 20

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Question 21

What is a mixed tumor?

Answer 21

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Question 22

Mixed tumors are monoclonal, what does this mean?

Answer 22

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Question 23

Mixed tumour contains representative of a single germ layer, give examples of theses?

Answer 23

Pleomorphic adenoma
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Question 24

Teratomas resemblance normal derivatives of?

Answer 24

More than one germ layer, arises from totipotent cells
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Question 25

Define Harmatoma?

Answer 25

Malformation of a mass of disorganized but matured specialized cells or tissues indiginous to a particular Site eg Odontoma Slide 35

Question 26

Define Choristoma? Nomenclature of Misnormer

Answer 26

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Question 27

List the role of factors that lead to the pathogenesis of neoplasm? [5]

Answer 27

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Question 28

Most cancers are ----------------------- butsome are ----------------------?[2]

Answer 28

1. Sporadic (random, isolated, scattered) 2. Familial

Question 29

What are the features that characterized familial cancers?

Answer 29

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Question 30

Explain Genetic predisposition to cancer?

Answer 30

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Question 31

Explain Age as a predisposing factor to developing CA?

Answer 31

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Question 32

List CA that affects children? [6]

Answer 32

WRRONL Slide 40

Question 33

How does the environment lead to development of carcinomas?

Answer 33

Slide 41-42

Question 34

Explain how acquired factors predispose people to Neoplasm?

Answer 34

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Question 35

Explain the acquired predisposing factors to neoplasm?

Answer 35

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Question 36

Define a precursor lesion

Answer 36

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Question 37

Differentiate between precursor lesion and precursor condition table

Answer 37

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Question 38

Deficiency of ----------------- increase risk of cancer?

Answer 38

1. T-cell immunity Slide 44

Question 39

Discuss cellular and molecular Hallmarks of CAancer? [8]

Answer 39

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Question 40

Define carcinogenic?

Answer 40

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Question 41

Genetic change in carcinogenesis can be due? [3]

Answer 41

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Question 42

Define genetic hypothesis?

Answer 42

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Question 43

What are the targets for cancer causing mutations (regulatory) ?

Answer 43

Four classes Slide 50

Question 44

Discuss Proto-oncogene?

Answer 44

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Question 45

Explain the MoA of Proto-oncogene? [4]

Answer 45

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Question 46

Anti cancer drugs target?

Answer 46

Oncogenes Slide 52

Question 47

Genetic mechanisms associated with oncogene activation are? [4]

Answer 47

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Question 48

What does tumo7r suppressor genes need?

Answer 48

1. Both alleles to be damaged for transformation to occur

Question 49

Dicuse the function of Tumour suppressor genes?

Answer 49

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Question 50

Etiology over cancer: carcinogenic agents? [3]

Answer 50

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