Negative Stranded and Double stranded RNA Viruses

Question 1

Late complication of measles. Pathogenesis.

Answer 1

Subacute sclerosing panencephalitis (SSP)

Defective measles virus persist in brain (act as slow virus) ▶️ chronic CNS degeneration

Question 2

Lung involvement of measles

Answer 2

Giant cell pneumonia (warthin-finkeldey cells)

Question 3

Complications of mumps

Answer 3

Pancreatitis
Orchitis ▶️ infertility in males
Meningoencephalitis

Question 4

Diseases on infants caused by parainfluenza virus

Answer 4

Cold
Pneumonia
Bronchiolitis
Croup

Question 5

Most affected population by respiratory syncytial virus (RSV) and diseases related

Answer 5

Infants/preemies
Bronchiolitis, atypical pneumonia

*adults - colds

Question 6

Clinical presentation of rabies and diagnosis.

Answer 6

• flu-like prodrome ▶️ hydrophobia ▶️ hallucination ▶️ coma ▶️ death
• clinical, negri bodies (brain Bx), DFA, PCR

Question 7

Which influenza virus make antigenic shift, what does it imply?

Answer 7

Influenza A ▶️ reassortment of genome segments ▶️ coinfection with 2 strains ▶️ new agent, no immunity ▶️ pandemic

Question 8

Rodent excrement contact (aerosol) during spring and early summer, hard myalgia and acute respiratory distress. Disease and region of high incidence

Answer 8

Hantavirus pulmonary syndrome

Four corners region

Question 9

Diseases associated with reovirus. Features of its viral family.

Answer 9

Common cold, Gastroenteritis

Double stranded RNA, virion-associated transcriptase, naked