Narcotics (Opioids) - for severe pain only

Question 1

Morphine

Answer 1

Mu-opioid receptor (MOR) agonist - for severe analgesia, mood alteration, antitussive (anti-cough), sedation

Question 2

Codeine

Answer 2

demethylated into morphone; Mu-opioid receptor (MOR) agonist - for severe analgesia, mood alteration, antitussive (anti-cough), sedation

Question 3

Tramadol

Answer 3

Mu-opioid receptor (MOR) agonist (weak and some NE/5HT uptake inhibition; synthetic codeine analog - for moderate analgesia (less constipation side effects)

Question 4

Fentanyl

Answer 4

Mu-opioid receptor (MOR) agonist - for severe analgesia (very strong), long half-life - don’t change dose before a week goes by

Question 5

Methadone

Answer 5

Mu-opioid receptor (MOR) agonist; very long acting - for chronic severe pain and heroin or opiod addicts

Question 6

Oxycodone

Answer 6

Mu-opioid receptor (MOR) agonist - for severe pain, very effective but highly abused

Question 7

Meperidine

Answer 7

(Demerol) Mu-opioid receptor (MOR) agonist, bad active metabolite, don’t use this

Question 8

Naloxone

Answer 8

Opioid receptors antagonist - for acute opioid toxicity (respiratory failure)

Question 9

Naltrexone

Answer 9

Mu-opioid receptor antagonist - for alcoholism