Antidepressants (increase serotonin and NE) Flashcards by Mike Fiacco

Q

Tranylcypromine

A

MAOI (both A and B) - for depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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Q

Phenelzine

A

MAOI (both A and B) - for depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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Q

Desipramine

A

Tricyclic; blocks reuptake of NE and 5-HT - for depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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Q

Imipramine

A

Tricyclic; blocks reuptake of NE and 5-HT - for depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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Q

Amitriptyline

A

Tricyclic; blocks reuptake of NE and 5-HT - for depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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Q

Nortriptyline

A

Tricyclic; blocks reuptake of NE and 5-HT - for depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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Q

Fluoxetine

A

SSRI (and some NE) - for depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism. serotonin syndrome with MAOi’s

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Q

Paroxetine

A

SSRI (and some NE) - for depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism. serotonin syndrome with MAOi’s

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Q

Sertraline

A

SSRI (and some NE) - for depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism. serotonin syndrome with MAOi’s

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Q

Escitalopram

A

SSRI (and some NE) - for depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism. serotonin syndrome with MAOi’s

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Q

Citalopram

A

SSRI (and some NE) - for depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism. serotonin syndrome with MAOi’s

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Q

Duloxetine

A

SNRI (“Duel”) - inhibits reuptake of 5-HT and NE - for depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism. serotonin syndrome with MAOi’s

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Q

Venlafaxine

A

SNRI - inhibits reuptake of 5-HT and NE - for depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism. serotonin syndrome with MAOi’s

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Q

Bupropion

A

Atypical - blocks DA and NE reuptake (unique antidepressant) - for all the different depressions and to maintain nicotine abstinence in quitting smokers, but increases risks for seizures

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Q

Murtazapine

A

5-HT antagonist, also inhibits 5-HT reuptake - for the depressions

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Q

Lithium

A

Mood stabilzer; unknown mechanism (lithium depletes 2ndary messengers IP3 and DAG, which are important in alpha-adrenergic and muscarininic-cholinergic transmission). Anti-manic/mood stabilizer (bipolar disorder) and long term cluster headache prevention. N/V are early signs of OD. Don’t give if prone to dehydration

Q

Ketamine

A

NMDA receptor antagonist => rapid antidepressant response (normally an IV anesthetic/street drug “special K”). could be miracle cure for depression? start on ketamine until antidepressants can kick in?