Narcotic Analgesics and Antagonist Flashcards
Narcotic analgesics-short term management of _________
moderate to severe pain
Action of Narcotic Analgesics
Opioids bind to opiate receptors in the CNS, where they act as agonists of endogenously occurring opioid peptides (endorphins). The result is _____
alteration to the perception of and response to pain.
Adverse Effects of Narcotics
(a) Respiratory Depression
(b) Light-headedness
(c) Constipation
(d) Nausea/vomiting
Contraindication/Warning/Caution for Narcs
(a) Head injury or increased ICP
(b) Hypoxia
(c) Hepatic impairment
(d) Hypersensitive to opioids or naloxone
What do you advise the patient of when giving narcotics?
respiratory risk
risk of constipation
Avoid concomitant use of narcotics with what when possible?
benzodiazepines or other CNS depressants
Opioid agonist or Antagonist?
(a) Partial Agonist: Buprenorphine
(b) Codeine: Codeine
(c) Fentanyl: Sublimaze
(d) Hydromorphone: Dilaudid
(e) Methadone: Dolophine
(f) Morphine sulfate: MS Contin
(g) Oxycodone: OxyContin
(h) Hydrocodone: Norco, Lortab, and Vicodin
agonist
___________ is a commonly used opioid antagonist drug which is competitive antagonists that bind to the opioid receptors with higher affinity than agonists
but do not activate the receptors. This effectively blocks the receptor, preventing the body from responding to opiates and endorphins.
Naloxone
What is a Narcotic Antagonist used for?
Overdose of a Narcotic
What is an adverse effect to Narcotic Antagonist
Acute opioid withdrawal
Contraindication for Narcotic Antagonist
Hypersensitivity to naloxone or any component of the formulation
Use naloxone with caution in patients with _______,
______ women, and opioid dependent patients.
CAD
Pregnant Women
