Names Names Names Flashcards

1
Q

Wolff-Chaikoff Effect

A

reduction in thyroid hormone production from too much iodine consumption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Jod Basedow Phenomenon

A

thyrotoxicosis if patient with iodine deficiency goiter is made iodine repleat
HYPERthyroidism (toxic multinodular goiter)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Wolff-Parkinson-White

Treatment?

A

A pre-excitation syndrome of the heart. caused by the presence of an abnormal accessory electrical conduction pathway between the atria and the ventricles, resulting in a unique type of supraventricular tachycardia
Delta waves on EKG
Tx: Procanimide and ablation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Chvostek’s Sign

A

When the facial nerve is tapped at the angle of the jaw, the facial muscles on the same side of the face will contract momentarily (typically a twitch of the nose or lips) because of hypocalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Trousseau’s Sign

A

bp cuff is placed around the arm and inflated to a pressure greater than systolic bp and held for 3 min, occluding the brachial artery. In the absence of blood flow, the patient’s hypocalcemia and subsequent neuromuscular irritability will induce spasm of the muscles of the hand and forearm. The wrist and metacarpophalangeal joints flex, the DIP and PIP joints extend, and the fingers adduct.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Trousseau’s Syndrome

A

migratory thrombophlebitis in cancer patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

DiGeorge Syndrome

A

22q11.2 deletion.
Third and Fourth pharyngeal pouches do not develop into the thymus.
Athymic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Sheehan’s Syndrome

A

hypopituitarism caused by ischemic necrosis due to blood loss and hypovolemic shock during and after childbirth.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Kimmelsteil-Wilson Nodules

A

mesangial expansion, GBM thickening, eosinophilic nodular glomerusclerosis seen on light microscopy in Diabetic glomerularnephropathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Kussmal’s Sign

A

a paradoxical rise in jugular venous pressure (JVP) on inspiration. It can be seen in some forms of heart disease and is usually indicative of limited right ventricular filling due to right heart failure.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Zollinger-Ellison Syndrome

A

gastrin secreting tumor of pancreas or duodenum causing recurrent ulcers.
stomach has rugal thickening with hypersecretion
can be spontaneous or part of MEN1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Plummer Disease

A

single toxic nodule (adenoma) which may present with the background of a suppressed multinodular goitre

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Kussmal Respirations

A

rapid and deep breathing sign of DKA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

deQuervain’s Thyroiditis

A

subacute thyroidisits
self-limited HYPOthyroidism often following flu like symptoms)
may be hyperthyroid early in course

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Reidel’s thyroidistis

A

thyroid is replaced by fibrous tissue

“rock-hard” thyroid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Homer-Wright pseudo rosette

A

small blue cells arranged around central pink neural fibrils

Seen in Neurobalstoma tumors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Waterhouse-Friderichsen syndrome

A

acute primary adrenal insufficiency due to adrenal hemorrhage
associated with N. meningitidis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Addison’s Disease

A

chronic primary adrenal insufficiency due to adrenal atrophy
presents: low aldosterone, cortisol, hypotension, hyperkalemia, acidosis, skin hyperpigmentation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Meigs Syndrome

A

triad of ascites, pleural effusion and benign ovarian tumor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Conn’s Syndrome

A

aldosterone- producing adenoma
causes primary hyperaldosteronism
treat with sprinolactone and/or surgical resection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Good Pasture’s

A

autoimmune disease in which antibodies attack the lungs and kidneys, leading to bleeding from the lungs and to kidney failure.

22
Q

Zellweger Syndrome

A

AR Leukodystrophy
mutations in genes that encode peroxins, proteins required for the normal assembly of peroxisomes. This causes impaired peroxisome function so tissues accumulate very long chain fatty acids (VLCFA) and branched chain fatty acids (BCFA) (normally degraded in peroxisomes)

23
Q

Chediak-Higashi Syndrome

A

AR disorder that arises from a microtubule polymerization defect which leads to a decrease in phagocytosis. The decrease in phagocytosis results in recurrent pyogenic infections, partial albinism and peripheral neuropathy.

24
Q

Karategner Syndrome

A

immotile cilia due to a dyein arm defect. results in male and female infertility, bronchiectasis and recurrent sinusitis
associated with situs inversus (organs on other side of body)

25
Alport Syndrome
usually X-linked dominant (can be recessive) collagen type 4 disorder effects basement membranes presents with glomerulonephritis, endstage kidney disease, hearing loss
26
Gilbert's Syndrome
mildly decrease UDP-glucuronyl transferase or decrease bilirubin uptake no clinical consequence
27
Cri-du-Chat syndrome
congenital micro-deletion of short arm of chromosome 5 | presents with microcephaly, mental retardation, high pitched crying/mewing, epicanthal folds, and cardiac abnormalities
28
Willams Syndrome
congenital microdeletion of long arm of chromosome 7 (including elastin gene) presents with elfin facies, mental retardation, hypercalcemia, well-developed verbal skills, extreme friendliness with strangers, cardiovascular problems
29
von Hippel Lindau
AD- deletion of VHL gene (tumor suppressor) on chromosome 3 resulting in expression of HIP (transcription factor) and activation of angiogenic growth factors. presents with hemagioblastomas of retina/cerebellum/medulla, multiple bilateral renal cell carcinomas and other tumors.
30
Osler-Weber-Rendu Syndrome
Hereditary hemorrhagic telangiectasia AD- blood vessel disorder presenting with telangiectasia, recurrent epistaxis, skin discoloration, and arteriovenous malformations
31
Lesch-Nyhan
defective purine salvage from absence of HGPRT (converts hypoxanthine to IMP and guanine to GMP) results in excess uric acid and denovo purine synthesis presents with retardation, self-mutilation, agression, hyperuricemia, gout, and choreoathetosis
32
Crigler-Najjar Syndrome
absent UDP-glucuronyl transferase presents early in life and patients die withina few years presents with jaundince, kernicterus, increase in unconjugated bilirubin tx: plasmapharesis and phototherapy
33
Dubin-Johnson Syndrome
conjugated hyperbilirubinemia due to defective liver excretion grossly black liver but benign and asymmptomatic
34
Courvoisier's Sign
obstructive jaundice with palpable gallbladder
35
Budd-Chiari Syndrome
occlusion of IVC or hepatic veins with centrilobar congestion and necrosis leading to congestive liver disease (note absent JVD on PE)
36
Reye's Syndrome
rare, fatal childhood hepatoencephalopathy associated with viral infections (esp VZV and influenza B) that has been treated with alicylates (asprin)
37
Hartnup's Disease
AR disorder with defective neutral amino acid transporter on renal and intestinal epithelial cells causes tryptophan excretion in urine and decreased absorption from gut causes pellagra
38
Homan's Sign
tender calf muscle upon dorsiflexion indicates DVT
39
Murphy's Sign
Positive (indicative of gallstones) if patient has inspiration arrest on deep palpation (over gallbladder area) due to pain
40
Gardner's Syndrome
familial adenomatous polyposis with osseous and soft tissue tumors, retinal hyperplasia
41
Turcot's Syndrome
familial adenomatous polyposis with malignant CNS tumor
42
Cowden Syndrome
rare AD multiple hamartoma syndrome
43
Peutz-Jeghers
AD - multiple non-malignant hamartomas throughout GI tract with hyperpigmented mouth, lips, hands, and genitalia associated with increased risk of colorectal cancer and other visceral malignancies
44
Berger's Disease
IgA Nephropathy related to Henoch-Schonlein Presents with URI or acute gastroenteritis See mesangial proliferation on light microscopy, mesangial IC deposits on EM, and IgA deposits in mesangium on immunoflorescence
45
Henoch-Schonlein
skin and multi-organ disease in kids, often preceded by an infection, like pharyngitis. Skin has palpable purpura with joint and abdominal pain. Kidneys can be involved, with small amounts of protein and blood in the urine. Can progress to chronic kidney disease
46
Takosubo's cardiomyopathy
non-ischaemic cardiomyopathy in which there is a sudden temporary weakening of the myocardium. weakening can be triggered by emotional stress, such as the death of a loved one, a break-up, or constant anxiety, the condition is also known as broken heart syndrome
47
Haldane Effect
in the lungs, Oxygenation of Hb promotes dissociation of H+ from Hb,shiftingthe equilibrium toward CO2 formation; therefore CO2 is released from RBCs
48
Bohr Effect
in peripheral tissue, an increase in H+ from metabolism shifts curve to the right, unloading O2
49
Virchow's Triad
1. Stasis 2. Hypercoaguability 3. Endothelial Damage * *can lead to pulmonary embolis
50
Cruschman's Spirals
shed epithelium from mucus plugs seen in Asthma patients
51
Reid Index
Thickness of glad layer/ total thickness of bronchiolar wall * used to measure airway obstruction * *Reid Index of >50 = Chronic bronchitis
52
Chagas Disease
dilated cardiomyopathy, megacolon, megaesophagus (achalasia) typically in South America caused by Trypsanosoma cruzi