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comlex > Cancer Genes > Flashcards

Cancer Genes Flashcards

1
Q

abl

A

Oncogene
Associated with CML
Gene product: tyrosine kinase

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2
Q

c-myc

A

Oncogene
Associated with Burkitt’s
Gene Product: Transcription Factor

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3
Q

bcl-2

A

Oncogene
Associated with follicular and undifferentiated lymphomas (inhibits apoptosis)
Gene product: anti-apoptotic molecule

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4
Q

erb-B2

A

Oncogene
Associated with breast, ovarian, and gastric carcinomas
Gene product: tyrosine kinase

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5
Q

ras

A

Oncogene
Associated with colon carcinoma
Gene product: GTPase

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6
Q

L-myc

A

oncogene
associated with lung cancer
gene product: transcription factor

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7
Q

N-myc

A

Oncogene
Associated with Neuroblastoma
Gene product: Transcription factor

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8
Q

ret

A

Oncogene
Associated with MENIIA and IIB
Gene product: Tyrosine kinase

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9
Q

c-kit

A

Oncogene
Associated with gastrointestinal stromal tumor
Gene product: Cytokine receptor

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10
Q

Rb

A

Tumor Supressor
Associated with Retinoblastoma and osteosarcoma
Gene Product: blocks G1->S phase of cell cycle

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11
Q

p53

A

Tumor Suppressor
Associated with most human cancers, Li-Fraumeni syndrome
Gene product: blocks G1->S phase of cell cycle

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12
Q

BRCA1

A

Tumor suppressor
Associated with Breast adn ovarian cancer
Gene product: DNA repair protein

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13
Q

BRCA2

A

Tumor Suppressor
Associated with Breast cancer
Gene product: DNA repair protein

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14
Q

p16

A

Tumor Suppressor

Associated with Melanoma

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15
Q

APC

A

Tumor Suppressor

Associated with Colorectal Cancer (associated with Familial Adenomatous Polyposis)

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16
Q

WT1

A

Tumor Suppressor

Associated with Wilm’s Tumor

17
Q

NF1

A

Tumore Suppressor

Associated with Neurofibromatosis Type 1

18
Q

NF2

A

Tumor Suppressor

Associated with Neurofibromaosis Type 2

19
Q

DPC

A

Tumor Suppressor
Associated with Pancreatic Cancer
(DPC- Deleted in Pancreatic Cancer)

20
Q

DCC

A

Tumor Suppressor
Associated with Colon Cancer
(DCC- Deleted in Colon Cancer)

comlex (18 decks)

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