Immunology

Question 1

Primary lymph drainage site of upper limb and lateral breast

Answer 1

Axillary

Question 2

Primary lymph node drainage site of stomach

Answer 2

Celiac

Question 3

Primary lymph node drainage site of duodenum and jejunum

Answer 3

Superior mesenteric

Question 4

Primary lymph node drainage site of sigmoid colon

Answer 4

Colic to inferior mesenteric

Question 5

Primary lymph node drainage site of rectum

Answer 5

Internal iliac

Question 6

Primary lymph node drainage site of anal canal

Answer 6

Superficial inguinal

Question 7

Primary lymph node drainage site of testes

Answer 7

Superficial and deep plexuses to para-aortic

Question 8

Primary lymph node drainage site of scrotum

Answer 8

Superficial inguinal

Question 9

Primary lymph node drainage site of thigh (superficial)

Answer 9

Superficial inguinal

Question 10

Primary lymph node drainage site of lateral side of dorsum of foot

Answer 10

Popliteal

Question 11

Associated disease with HLA-A3

Answer 11

Hemochromatosis

Question 12

Associated diseases with HLA-B27

Answer 12

Psoriasis, Ankylosing spondylitis, inflammatory bowel disease, Reiter’s syndrome

(PAIR)

Question 13

Associated disease with HLA-B8

Answer 13

Graves Disease

Question 14

Associated disease with HLA-DR2

Answer 14

Multiple sclerosis
Hay fever
SLE
Goodpastures

Question 15

Associated disease with HLA-DR3

Answer 15

DM-1

Question 16

Associated disease with HLA-DR4

Answer 16

RA

DM-1

Question 17

Associated disease with HLA-DR5

Answer 17

Pernicious Anemia (B12deficiency)
Hashimoto's thyroiditis

Question 18

Associated disease with HLA-DR7

Answer 18

Steroid responsive nephrotic syndrome

Question 19

Ig that Fixes complement and crosses placenta

Answer 19

IgG

Question 20

Ig that activates eosinophilia

Answer 20

IgE

Question 21

Ig that is an antigen receptor on B cell surface

Answer 21

IgM

Question 22

Ig that binds mast cells and basophils

Answer 22

IgE

Question 23

Ig that fixes complement but does NOT cross the placenta

Answer 23

IgM

Question 24

Ig with unclear function

Answer 24

IgD

Question 25

Ig produced in the primary (immediate) response to an antigen

Answer 25

IgM

Question 26

Ig that is produced in the secondary (delayed) response to antigen

Answer 26

IgG

Question 27

Ig that mediates type 1 hypersensitivity

Answer 27

IgE

Releases histamine

Question 28

Ig that neutralizes bacterial toxins and viruses

Answer 28

IgG

Question 29

Ig that opsonizes bacteria

Answer 29

IgG

Question 30

Ig that prevents the attachment of bacteria and viruses to mucous membranes

Answer 30

IgA

Question 31

Activates macrophages and Th1 cells

Suppresses Th2

Answer 31

INF-gamma

Question 32

Causes fever and acute inflammation, induces chemokine secretion

Answer 32

IL-1

Question 33

Causes fever and stimulates production of acute phase proteins

Answer 33

IL-6

Question 34

bruton agammaglobulinemia

Answer 34

X-linked recessive disorder, which is caused by a defect in the BTK tyrosine kinase gene, leading to a lack of B cells and inefficient opsonization

Question 35

anti-inflammatory cytokines (2)

Answer 35

IL-10, TGF-B

Question 36

Monocyte/Macrophage cell surface marker

Answer 36

CD14

Question 37

c-ANCA -antibodies against?

Answer 37

autoantibodies against proteinase-3 and are highly specific for Wegener’s granulomatotis

Question 38

p-ANCA- antibodies against?

Answer 38

Autoantibodies against myeloperoxidase