Myocarditis, Pericarditis, and Cardiomyopathies

Question 1

______ from artificial joints can be associated with toxic cardiomyopathy

Answer 1

Cobalt

Question 2

______ is/are protective against cardiac hypertrophy via epigenetic mechanisms

Answer 2

HDAC9

Question 3

______ promote(s) cardiac hypertrophy via epigenetic mechanisms

Answer 3

HDAC1 and HDAC2

Question 4

_______: mechanisms for changing gene transcription without changing the underlying DNA sequence

Answer 4

Epigenetics

Question 5

Amyloidosis is most commonly associated with which neoplasm?

Answer 5

Plasma Cell myeloma

Question 6

Cause of constrictive pericarditis

Answer 6

Scarring/loss of elasticity secondary to cardiac surgery, infection, or radiation

Question 7

Causes of pericarditis (4)

Answer 7

Viral illness, Connective Tissue Disease, Uremia, Metastatic tumors

Question 8

Causes of restrictive cardiomyopathy (4)

Answer 8

Amyloidosis, Hemochromatosis, Scleroderma, Radiation therapy

Question 9

Chemotherapy drug with dose-dependent cardiac toxicity

Answer 9

Adriamycin

Question 10

EKG observation of pericarditis

Answer 10

Diffuse ST elevation

Question 11

EKG observation of tamponade

Answer 11

Electrical alternans

Question 12

Histone _______ (H___) decrease gene expression

Answer 12

deacetylases; DACs

Question 13

Histone _______ promote gene transcription

Answer 13

acetyltransferases

Question 14

Histone modifying proteins primarily act on _____ residues of the histone tails.

Answer 14

Lysine

Question 15

Key detail of pericarditis presentation

Answer 15

Chest pain that changes with breathing or position

Question 16

Most common cardiac neoplasms in infants/children

Answer 16

Rhabdomyoma

Question 17

Most common cardiac neoplasms in teens/adults

Answer 17

Cardiac Myxoma

Question 18

Most common complication of cardiac myxoma

Answer 18

thromboembolism

Question 19

Most common extra heart sound in acute myocarditis

Answer 19

S3

Question 20

Most common location of cardiac myxoma

Answer 20

Left atrium

Question 21

Most common viral cause of acute myocarditis

Answer 21

Coxsackie B

Question 22

Name the disease process where proteins deposit (as beta-pleated sheets) around blood vessels and in the parenchyma of various organs

Answer 22

Amyloidosis

Question 23

Treatment for Acute myocarditis

Answer 23

Heart Failure Management (Diuresis, Beta-blockers, ACEIs), treatment for underlying condition

Question 24

Treatment of constrictive pericarditis

Answer 24

Surgical stripping of pericardium

Question 25

Treatment of pericarditis

Answer 25

NSAIDs

Question 26

What pathology? Inflammatory disease often presenting within two weeks of a URI with symptoms of heart failure, cardiogenic shock, or arrhythmias?

Answer 26

Acute Myocarditis

Question 27

Which cardiomyopathy? May cause thromboembolism

Answer 27

Dilated

Question 28

Which cardiomyopathy? May present with arrhythmia

Answer 28

Dilated and Restrictive

Question 29

Which cardiomyopathy? Normal systolic function

Answer 29

Hypertrophic and Restrictive

Question 30

Which cardiomyopathy? Usually familial

Answer 30

Hypertrophic

Question 31

Which cardiomyopathy? Usually idiopathic

Answer 31

Dilated