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Cardiovascular System > Anticoagulants, Anti-Platelet Agents, and Vasodilators > Flashcards

Anticoagulants, Anti-Platelet Agents, and Vasodilators Flashcards

1
Q

Advantages of Hirudin/Dabigatran over Warfarin

A

No monitoring, No dietary restrictions, Fewer strokes and intracranial hemorrhage

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2
Q

Advantages of Xa inibitors over Warfarin

A

No monitoring, No dietary restrictions, Fewer strokes and intracranial hemorrhage

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3
Q

Disadvantages of Hirudin/Dabigatran over Warfarin

A

Shorter acting (bid), renal dosing required

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4
Q

Disadvantages of Xa inhibitors over Warfarin

A

Cannot monitor, no specific antidote, shorting acting, may require renal dosing

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5
Q

Treatment of Stable Angina

A

Nitrates, Calcium channel blockers, Beta blockers

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6
Q

Treatment of Unstable Angina

A

Nitrates, Beta blockers, anti-thrombotics

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7
Q

Treatment of Variant Angina

A

Nitrates, Calcium channel blockers

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8
Q

Use: Abciximab/Epitifibatide/Tirofiban

A

Some PCIs

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9
Q

Use: ADP receptor antagonists

A

AMI, PCIs, some UA

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10
Q

Use: aspirin

A

ACS, PCIs, secondary prevention of AMI and stroke

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11
Q

Use: Calcium channel blockers

A

Angina, arrhythmia, hypertension, subarachnoid hemorrhage, inhibit premature labor

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12
Q

Use: Dipyridamole

A

Secondary prevention of stroke (with aspirin)

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13
Q

Use: Fondaparinux

A

UA, AMI, VTE, stroke, post-op thromboembolism

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14
Q

Use: Heparin

A

UA, AMI, VTE, stroke, post-op thromboembolism

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15
Q

Use: Hirudin/Dabigatran

A

Atrial Fibrillation

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16
Q

Use: LMWH

A

UA, AMI, VTE, stroke, post-op thromboembolism

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17
Q

Use: metoprolol

A

Angina with arrhythmia or hypertension

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18
Q

Use: nitrates

A

Angina; perioperative hypertension

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19
Q

Use: Ranolazine

A

Angina (Patients who poorly tolerate Beta-blockers)

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20
Q

Use: Rivaroxaban/Apixiban/Edoxaban

A

Atrial Fibrillation

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21
Q

Use: Warfarin

A

Atrial fibrillation, VTE

22
Q

Which drug? ADP receptor antagonist

A

Clopidogrel, Prasugrel, Ticagrelor

23
Q

Which drug? Adverse effects of throbbing headache, orthostatic hypotension, reflex tachycardia, facial flushing

A

Nitrates

24
Q

Which drug? Adverse reaction of thrombocytopenia

A

Heparin

25
Q

Which drug? Anticoagulant with many drug-drug interactions and CYP450 metabolism

A

Warfarin

26
Q

Which drug? Anticoagulant with renal dosing required

A

Hirudin/Dabigatran, Rivaroxaban, Apixiban, Edoxaban

27
Q

Which drug? Anticoagulants that do not cross the placenta

A

Heparin, LMWH, Fondaparinux

28
Q

Which drug? Anticoagulants with IV/SC administration

A

Heparin, LMWH, Fondaparinux

29
Q

Which drug? Blocks phosphodiesterase breakdown of cAMP

A

Dipyridamole

30
Q

Which drug? Calcium channel blockers with vasculature and cardiac selectivity

A

Verapamil, Diltiazem

31
Q

Which drug? Calcium channel blockers with vasculature selectivity

A

Nifedipine, Amlodipine, Felodipine

32
Q

Which drug? combine with antithrombin III to inactivate Xa

A

LMWH, Fondaparinux

33
Q

Which drug? combines with antithrombin III to inactivate clotting factors IIa, Xa (IXa, XIa, XIIa)

A

Heparin

34
Q

Which drug? Contraindications of asthma, peripheral vascular disorders

A

Metoprolol

35
Q

Which drug? conversion to NO nears VSMCs results in activation of guanylate cyclase and smooth muscle relaxation

A

Nitrates

36
Q

Which drug? decrease myocardial oxygen requirements via reduction of heart rate, blood pressure, and contractility

A

Beta-blockers: Metoprolol

37
Q

Which drug? Directly inhibit IIa (thrombin)

A

Hirudin, Dabigatran

38
Q

Which drug? Directly inibit Xa

A

Rivaroxaban, Apixiban, Edoxaban

39
Q

Which drug? IIb/IIIa receptors to block platelet-platelet binding to inhibit all pathways of platelet aggregation

A

Abciximab/Eptifibatide/Tirofiban

40
Q

Which drug? inhibit synthesis of Vitamin-K dependent factors

A

Warfarin

41
Q

Which drug? inhibition of COX-1 mediated thromboxane synthesis in platelets

A

Aspirin

42
Q

Which drug? Inhibits late sodium current

A

Ranolazine

43
Q

Which drug? IV antiplatelet drugs

A

Abciximab/Eptifibatide/Tirofiban

44
Q

Which drug? LMWHs

A

Enoxaparin, Dalteparin

45
Q

Which drug? monitored with APTT

A

Heparin

46
Q

Which drug? Monitored with Ecarin clotting time (ECT)

A

Hirudin, Dabigatran

47
Q

Which drug? Monitored with PT

A

Warfarin

48
Q

Which drug? Oral anticoagulant

A

Warfarin, Hirudin/Dabigatran, Rivaroxaban/Apixaban/Edoxaban

49
Q

Which drug? Significant overdose treatment of Warfarin

A

Vitamin K, Prothrombin complex concentrate

50
Q

Which drug? Used to treat heparin overdose

A

Protamine

51
Q

Which drug? Vasodilator administered sustained release orally, sublingually, transdermally, and parenterally

A

Nitrates

52
Q

Which drug? Vasodilator with QT prolongation

A

Ranolazine

Cardiovascular System (11 decks)

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