Anticoagulants, Anti-Platelet Agents, and Vasodilators

Question 1

Advantages of Hirudin/Dabigatran over Warfarin

Answer 1

No monitoring, No dietary restrictions, Fewer strokes and intracranial hemorrhage

Question 2

Advantages of Xa inibitors over Warfarin

Answer 2

No monitoring, No dietary restrictions, Fewer strokes and intracranial hemorrhage

Question 3

Disadvantages of Hirudin/Dabigatran over Warfarin

Answer 3

Shorter acting (bid), renal dosing required

Question 4

Disadvantages of Xa inhibitors over Warfarin

Answer 4

Cannot monitor, no specific antidote, shorting acting, may require renal dosing

Question 5

Treatment of Stable Angina

Answer 5

Nitrates, Calcium channel blockers, Beta blockers

Question 6

Treatment of Unstable Angina

Answer 6

Nitrates, Beta blockers, anti-thrombotics

Question 7

Treatment of Variant Angina

Answer 7

Nitrates, Calcium channel blockers

Question 8

Use: Abciximab/Epitifibatide/Tirofiban

Answer 8

Some PCIs

Question 9

Use: ADP receptor antagonists

Answer 9

AMI, PCIs, some UA

Question 10

Use: aspirin

Answer 10

ACS, PCIs, secondary prevention of AMI and stroke

Question 11

Use: Calcium channel blockers

Answer 11

Angina, arrhythmia, hypertension, subarachnoid hemorrhage, inhibit premature labor

Question 12

Use: Dipyridamole

Answer 12

Secondary prevention of stroke (with aspirin)

Question 13

Use: Fondaparinux

Answer 13

UA, AMI, VTE, stroke, post-op thromboembolism

Question 14

Use: Heparin

Answer 14

UA, AMI, VTE, stroke, post-op thromboembolism

Question 15

Use: Hirudin/Dabigatran

Answer 15

Atrial Fibrillation

Question 16

Use: LMWH

Answer 16

UA, AMI, VTE, stroke, post-op thromboembolism

Question 17

Use: metoprolol

Answer 17

Angina with arrhythmia or hypertension

Question 18

Use: nitrates

Answer 18

Angina; perioperative hypertension

Question 19

Use: Ranolazine

Answer 19

Angina (Patients who poorly tolerate Beta-blockers)

Question 20

Use: Rivaroxaban/Apixiban/Edoxaban

Answer 20

Atrial Fibrillation

Question 21

Use: Warfarin

Answer 21

Atrial fibrillation, VTE

Question 22

Which drug? ADP receptor antagonist

Answer 22

Clopidogrel, Prasugrel, Ticagrelor

Question 23

Which drug? Adverse effects of throbbing headache, orthostatic hypotension, reflex tachycardia, facial flushing

Answer 23

Nitrates

Question 24

Which drug? Adverse reaction of thrombocytopenia

Answer 24

Heparin

Question 25

Which drug? Anticoagulant with many drug-drug interactions and CYP450 metabolism

Answer 25

Warfarin

Question 26

Which drug? Anticoagulant with renal dosing required

Answer 26

Hirudin/Dabigatran, Rivaroxaban, Apixiban, Edoxaban

Question 27

Which drug? Anticoagulants that do not cross the placenta

Answer 27

Heparin, LMWH, Fondaparinux

Question 28

Which drug? Anticoagulants with IV/SC administration

Answer 28

Heparin, LMWH, Fondaparinux

Question 29

Which drug? Blocks phosphodiesterase breakdown of cAMP

Answer 29

Dipyridamole

Question 30

Which drug? Calcium channel blockers with vasculature and cardiac selectivity

Answer 30

Verapamil, Diltiazem

Question 31

Which drug? Calcium channel blockers with vasculature selectivity

Answer 31

Nifedipine, Amlodipine, Felodipine

Question 32

Which drug? combine with antithrombin III to inactivate Xa

Answer 32

LMWH, Fondaparinux

Question 33

Which drug? combines with antithrombin III to inactivate clotting factors IIa, Xa (IXa, XIa, XIIa)

Answer 33

Heparin

Question 34

Which drug? Contraindications of asthma, peripheral vascular disorders

Answer 34

Metoprolol

Question 35

Which drug? conversion to NO nears VSMCs results in activation of guanylate cyclase and smooth muscle relaxation

Answer 35

Nitrates

Question 36

Which drug? decrease myocardial oxygen requirements via reduction of heart rate, blood pressure, and contractility

Answer 36

Beta-blockers: Metoprolol

Question 37

Which drug? Directly inhibit IIa (thrombin)

Answer 37

Hirudin, Dabigatran

Question 38

Which drug? Directly inibit Xa

Answer 38

Rivaroxaban, Apixiban, Edoxaban

Question 39

Which drug? IIb/IIIa receptors to block platelet-platelet binding to inhibit all pathways of platelet aggregation

Answer 39

Abciximab/Eptifibatide/Tirofiban

Question 40

Which drug? inhibit synthesis of Vitamin-K dependent factors

Answer 40

Warfarin

Question 41

Which drug? inhibition of COX-1 mediated thromboxane synthesis in platelets

Answer 41

Aspirin

Question 42

Which drug? Inhibits late sodium current

Answer 42

Ranolazine

Question 43

Which drug? IV antiplatelet drugs

Answer 43

Abciximab/Eptifibatide/Tirofiban

Question 44

Which drug? LMWHs

Answer 44

Enoxaparin, Dalteparin

Question 45

Which drug? monitored with APTT

Answer 45

Heparin

Question 46

Which drug? Monitored with Ecarin clotting time (ECT)

Answer 46

Hirudin, Dabigatran

Question 47

Which drug? Monitored with PT

Answer 47

Warfarin

Question 48

Which drug? Oral anticoagulant

Answer 48

Warfarin, Hirudin/Dabigatran, Rivaroxaban/Apixaban/Edoxaban

Question 49

Which drug? Significant overdose treatment of Warfarin

Answer 49

Vitamin K, Prothrombin complex concentrate

Question 50

Which drug? Used to treat heparin overdose

Answer 50

Protamine

Question 51

Which drug? Vasodilator administered sustained release orally, sublingually, transdermally, and parenterally

Answer 51

Nitrates

Question 52

Which drug? Vasodilator with QT prolongation

Answer 52

Ranolazine