Myeloma Flashcards
1
Q
Definition
A
Cancer of plasma B cells which produces antibodies which are potentially harmful to the kidneys
2
Q
Where do collections of abnormal plasma cells accumulate?
A
Bone marrow
3
Q
What is the abnormal antibody that is produced?
A
Paraprotein
4
Q
What is the significance of the kidney in this disease?
A
Normal glomerulus becomes overwhelmed by the huge amounts of protein
5
Q
Clinical features
A
Bone pain Bone destruction - hypercalcaemia Back pain Renal failure Weakness Weight loss
6
Q
Glomerular renal manifestations
A
Amyloidosis
Monoclonal immunological desposition
7
Q
Tubular renal manifestations
A
Light chain cast nephropathy
8
Q
Investigations
A
Bloods Urine - Bence jones protein Bone marrow biopsy Skeletal survey Renal biopsy
9
Q
Management
A
Stop nephrotoxic drugs
Manage hypercalcaemia
Chemotherapy
Stem cell transplant
