Mycobacteria leprae

Question 1

Biology?

Answer 1

Prefer lower temp

obligate anaerobe

acid-fast

facultative intracellular

mycolic acid cell wall

Question 2

2 forms of leprae?

which is more severe?

Answer 2

Tuberculoid = Less severe

Lepromatous = More severe

Question 3

what cells does m. leprae target?

Answer 3

dermal macrophages and Schwann cells of peripheral nerves

Question 4

2 disease manifestations occur due to what response?

Answer 4

Th1 or Th2

Question 5

m. leprae with high Th1 will be?

Answer 5

tuberculoid leprae

Question 6

m. leprae with high Th2 will be?

Answer 6

lepromatous

Question 7

what immunity will be highly responding to tuberculoid leprosy?

Answer 7

Cell mediated because its Th1

Question 8

what immunity will be highly responding to lepromatous leprosy?

Answer 8

humoral immunity because it is Th2

Question 9

what lesions are seen in tuberculoid leprosy?

Answer 9

Flat macular lesions

Question 10

what lesions are seen in lepromatous leprosy?

Answer 10

Raised papular lesions

Question 11

which leprosy will lead to a presentation of loss of feeling?

Answer 11

both

Question 12

what are the symptoms of tuberculoid leprosy?

Answer 12

• Maculoanasethetic patch with hypopigmented centre.
• Skin is dry, hairless & insensitive.

Question 13

what symptoms wil be seen with Lepromatous Leprosy?

Answer 13

• Glistening erythematous or skin-colored papules, nodules & plaques.
• Ears: Thickened & nodular.
• Legs: Edema & ulceration.