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Infectious Disases Microbiology > Mycobacteria > Flashcards

Mycobacteria Flashcards

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Biology 101 flashcards
1
Q

Structures of mycobacteria’s cell membrane and cell wall?

A

Mannophosphoinositide var membrandan başlıyor
Lipoarabinomannan varyine membranda cell wallı da delip geçiyor
Thick peptidoglycan layer
Arabinogalactan starting from peptidoglycan
Mycolic acid at the top of arabinogalactan

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2
Q

On pathogenic mycobacteria there is a special mycolic acid named also cord factor ____

A

trehalose 6-6’ dimycolic acid

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3
Q

What is atypical mycobacterium?

A

Mycobacterium that causes other stuff than tuberculosis.Synonyms are NTM,MOTT

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4
Q

General properties of mycobacteria?

A

Waxy(bcs of highly rich lipid content in cell wall)
Very resistant to all environmental conditions and ab
AEROBİC
NON MOTİLE
NON TOXİGENİC
NON ENCAPSULATED

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5
Q

What is the major virulence factor of mycobacteria?

A

Cell Wall

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6
Q

What is the 3 major groups of mycobacteria?

A

Pathogenic
Opportunistic
Saprophytic

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7
Q

What are the pathogenic mycobacterias?

A

Mycobacterium tuberculosis complex and mycobacterium leprosy

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8
Q

What are the mycobacterium complex mycobacteriums?

A 
Mycobacterium tuberculosis
Mycobacterium bovis
Mycobacterium  africanum
Mycobacterium microti
Mycobacterium caprae
Mycobacterium  pinnipedil
Mycobacterium   canettii
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9
Q

Which mycobacterium is used for BCG vaccine formation?

A

M.bovis

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10
Q

Which mycobacterium can be misdiagnosed as tuberculosis?

A

M.kansaii

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11
Q

Which mycobacterium saprophytic and also a part of normal flora of skin and airways?

A

M.smegmatis

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12
Q

What are the 3 culture methods for mycobacterium?

A

Lowenstein-Jensen medium
Middlebrook medium
Liquid medium based (MGIT)

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13
Q

Lowenstein-Jensen medium contents?

A

Egg,Potato,Malachite green,Glycerol

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14
Q

Middlebrook medium contents?

A

Albumin,Agar,Dextrose,Catalase,NaCl

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15
Q

What are the microscopic examination methods for mycobacteria?

A

Ziehl Neelson method (acid fast bacteria)
Kinyoun method
Auramine rhodamine method(fluorochrome dyes)

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16
Q

What is the best lab method for tuberculosis?

A

İsolation by culture method

17
Q

What is the therapy method that WHO found for treatment for tuberculosis patients?

A

DOT (Direct Observation Therapy)

18
Q

What are the drugs for tuberculosis?

A 
FİRST 2 MONTHS 
İSONİAZİD
RİFAMPİN
PYRAZİNAMİDE
ETHAMBUTOL
LAST 4 MONTHS
İSONİAZİD 
RİFAMPİN
19
Q

What is DR,MDR and XDR?

A

DR:Resistance to any drug
MDR:Resistance to isoniazid and rifampin
XDR:In addition to MDR,resistance to quinolone and one injectable drug

20
Q

What is the major reasons of resistance of mycobacteria to ab?

A

High mycolic acid and

High rate of mutation

21
Q

What is resistance?

A

%1 growth in the presence of critical concentration of tuberculosis drug

22
Q

Tuberculoid Leprosy?

A 
Benign and non progressive
Macular skin lesions
Severe asymmetric nerve involvement
few bacilli in lesions
positive lepromin test
intact cell mediated immunity
23
Q

Lepramatous Leprosy?

A 
Malignant and progressive
Nodular skin lesions(Destructs bone and cartilage)
Symmetric nerve involvement
Abundant bacilli in lesions
Negative lepromin test
Deficient cell mediated immunity

Infectious Disases Microbiology (12 decks)

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