Bacillus Anthracis

Question 1

Bacillus is a _____ spore forming bacteria

Answer 1

obligate aerobic

Question 2

What are the lab finding of b.anthracis?

Answer 2

Large,flat,irregular
NON HEMOLYTİC COLONİES
Catalase +
Has a pink METACHROMOTİC (POLYSACCAHRİDE) Capsule

Question 3

What is the reservoir of b.anthracis?

Answer 3

Zoonotic
Seen usually in farmers,slaughterhouse,woolsorting,
or as a biologic warfare (inside envelopes)

Question 4

What are the entrance points of b.anthracis?

Answer 4

Skin
Lung
Intestines (last two are more severe,more rapidly developing and progressive)

Question 5

What is a common finding in b.anthracis patients?

Answer 5

Fluid in mediastinum we do THORACENTESİS

Question 6

What do we see in direct (blood) specimen and lab specimen in b.anthracis?

Answer 6

in direct(blood=alive) we see capsule
in lab we see spor formation

Question 7

What do we use as a chemoprophylaxis in b.anthracis?

Answer 7

Ciproflaxacin(has a high alveolar macrophage concentration)

Question 8

How can we make b.anthracis form capsule in lab

Answer 8

In %5 co2 concentration

Question 9

What is the two main virulence factors of b.anthracis?

Answer 9

Both of them are plasmid related
capsule–>Polypeptide capsule leads to S type of colonies(mucoid,smooth)
exotoxin–>another plasmid related
composed of 3 factors EF,LF,PA

Question 10

What is the most common form?

Answer 10

Cutaneous Anthrax

Question 11

How is the route of infection of b.anthracis?

Answer 11

animal–>human
bacilli cannot make you sick you need its spore!(spore formation takes place where there arent enough food like soil of animal etc.)