Gram Negative Bacilli

Question 1

What does Haemophilius require in agar?

Answer 1

X(Hemin) and V(NAD-Nicotinamide Adenine Dinucleotide)

Question 2

Haemophilus?

Answer 2

Small
Facultatively anaerob
Have endotoxin
Polysaccharide capsule
MOST VİRULENT ONE-->H.influenza TYPE B

Question 3

What are the gold standart for culture for hemophilius?

Answer 3

CSF and Synovial Fluid

Question 4

3 species of Haemophilus?

Answer 4

H.aegypticus–>Conjunctivitis
H.ducreyi–>Soft chancre(chancroid)
H.influenza

Question 5

WHAT İS THE MOST COMMON CAUSE OF MENİNGİTİS?

Answer 5

H.İNFLUENZA TYPE B

Question 6

What is the VİRULENCE FACTOR OF H.influenza type B?

Answer 6

PRP(Polyribosyl ribitol phosphate)—>

VACCİNES ARE AGAİNST PRP!!!

Question 7

Where is PRP FOUND on H.influenza type b?

Answer 7

CAPSULE

Question 8

What is Satellite Phenomenon?

Answer 8

Haemophilus growing around staphylococcus aureus in a media which there is no V OR X!!!
S.aureus lysis RBC—->X :)
S.aureus excretes—->V :)

Question 9

Bordetella?

Answer 9

Strictly aerob
Inhalation transmission
EXTREMELY SMALL

Question 10

Most important specie of Bordatella?

Answer 10

B.pertussis

Question 11

What is the virulence factor of B.pertussin?

Answer 11

Pertussis Toxin

Question 12

What is the mechanism of pertussis toxin?

Answer 12

inhibition of G protein–>increase in cAMP–>increase in respiratory secretions and mucus production–>WHOOPİNG COUGH!!!!!!!

Question 13

How is the Dx of bordetella?

Answer 13

Nasopharyngeal aspirate

Question 14

Prevention of bordatella?

Answer 14

ACELLULAR vaccine=inactivated pertussis toxin
filamentous hemagglutinin
pertactin

Question 15

What are the virulence factors of bordetella?

Answer 15

pertactin\
                                           attachment to respiratory cells
filamentous hemagglutinin/
fimbria
pertussis toxin

Question 16

3 Clinical stages of bordetella?

Answer 16

1) Catarrhal Stage
2) Paroxysmal Stage(WHOOPİNG COUGH)
3) Convalescent Stage