Muscles Flashcards
muscle fatigue
progressive weakness and loss of contractility from prolonged use of muscles
Factors in muscle fatigue: high-intensity/short time
- Potassium accumulation makes fiber less exciteable
- ADP accumulation - slows the cross bridge cycling of contraction
- P accumulation - inhibits Calcium release from SR and sensitivity of contractile mechinism
Factors in muscle fatigue: low-intensity, long-duration exercise
- fuel depletion - declining muscle glycogen and blood glucose leave less fuel for ATP synthesis (why runners eat high-carb before race to load muscles with extra glycogen)
- electrolyte loss - losing through sweat can decrease the muscle exciteability
- central fatigue - exercising generates ammonia which is absorbed by the brain and inhibits motor neurons
maximum oxygen uptake (Vo2max)
determines ability to maintain high-intensity for more than 4-5 minutes
is proportional to body size, larger in men, peaks at 20, and is greater in trained endurance atheletes
sedentary adult (35 milliliters/O2/min/kg of body weight) vs 70 ml/min in elite endurance atheletes
denervation atrophy
if a muscle nerve connection is severed or poisoned, muscle is paralyzed and atrophies
muscle endurance exercises
increased fatigue resistance - enhanced delivery and use of oxygen
jogging and swimming are good endurance exercise
slow-twitch fibers - grow more capillaries, mitochondria, glycogen as a result of conditioning
increased skeletal strength which increases RBC and oxygen transport capacity of the blood improves cardiovascular, respiratory, and nervous systems
deconditioning
if muscles not sufficiently active become weak and easily fatigued
Oxygen Debt / how to end it
post-exercise, heavy breathing
now called excess postexercise oxygen consumption
body needs Oxygen to regenerate ATP aerobically, regenerate creatine phospate, dispose of lactate, increased temp. uses more oxygen
remains elevated as long as 1 hr EPOC can be 6x typical consumption
Functions of Muscles
Movement (skeletal-locomotion, pumps heart, controls body openings/passageways, moves fluids)
Stability/posture
Stabilize joints - maintain tension on tendons
generate heat
control blood glucose
Purpose of all muscle
To convert ATP into the energy of motion (book)
muscle organ (components smallest to largest)
(see card)
tendons
attach muscles to bone at the origin and insertion
aponeuroses
tendon as a sheet - such as scalp, palmar aponeurosis
retinaculum
band of connective tissue “bracelet”
wrists/ankles
holds tendons in place
prime mover (agonist)
muscle producing most of the force of movement
synergist
muscle that is helping the prime mover
belly of muscle
largest/center of a fusiform muscle like the calf or biceps
intrinsic muscle
same region as use
Ex. hand muscle located in hand
extrinsic muscle
different region of origin
Ex. hand muscle origin in forearm
action
effect of muscle to produce or prevent a movement
fascicle
bundle of muscle fibers within a muscle
enclosed by perimysium
antagonist
muscle opposite the prime mover
antagonist pair
muscles around a joint - act together at times depending on movement (see class note)
fixator
holds a bone in place so another muscle can perform
Ex. rhomboids hold the scapula close to vertebral column while biceps contract, postural muscles hold bones steady
ensures bicep force moves radius rather than scapula
myofibril
myofibrils are bundles of myofilaments
long protein cords that fill up the majority of the sarcoplasm in muscle fibers
striated appearance because of overlapping myofilaments
each surrounded by sarcoplasmic reticulum
100s of sarcomeres end to end form
myofilament
The tiny filaments that make up myofibrils
thick - myosin
thin - actin
titin filaments
elastic proteins that ancor structures to z discs and M-line
helps stabalize the thick
prevents overstretching
recoils like a spring after the muscle is stretched
3 layers of collagenous connective tissue in skeletal muscle
endomysium
perimysium
epimysium
sarcomere
can be 100s in a muscle fiber
from z line to z line with the lighter Actin on the ends
gets shorter during muscle contraction
but fibers don’t change length/ they overlap
2 kinds of filaments
Myocin (thick)
Actin (thin)
Actin
thin myofilament
has a cover over the binding site by Tropomyacin
Troponin helps stabalize the cover
Myocin
thick myofilament
bundled with Actin
has glubular heads/cross bridges/extensions with binding sites for ATP, Actin, and ATPase
when muscle contracting, globular heads grab actin fibers and pull “power stroke”
Characteristics of a skeletal muscle fiber
long, single muscle cell
fast and strong contractions
striated - A bands and I bands
multi-nucleated along fiber edges, just under the sarcolemma
form the contours of the body
Smooth muscle fiber characteristics
visceral, non-striated, involuntary
slow and strong contractions
spindle shaped fibers
form the walls of hollow/visceral organs and tubes (stomach, bladder, respiratory tubes)
Cardiac Muscle Characteristics
synchronous contractions, involuntary
intercalcated discs, branching cells
only in heart
very light striations (microscopic)
Muscles comprise __-___% of total body weight and are the ________ machines of the body. Muscle presence in the human body includes over ____ muscle organs
Muscles comprise 40 – 50% of total body weight and are the movement machines of the body. Muscle presence in the human body includes over 650 muscle organs
In muscle cells:
cytoplasm is __________
plasma membrane is ____________
endoplasmic reticulum is _____________
cytoplasm is sarcoplasm
plasma membrane is sarcolemma
endoplasmic reticulum is sarcoplasmic reticulum
T-tubules
tubules in skeletal and cardiac muscle
finger like invaginations of the sarcolemma
Terminal cisternae
sac-like structures of sarcoplasmic reticulum on each side of a t-tubule
What makes triad for release are re-uptake of calcium in the sarcoplasm for contraction process
T-tubule invagination and adjacent terminal cisternae on either side
contractility
ability for muscle cells to shorten/produce tension within self when adequate stimulus is received
irritability
ability to receive/respond to stimulus
neuromuscular junction
association site of motor nerve and muscle (synaptic cleft - don’t touch)
interstitial fluid
fills the synaptic cleft between motor neuron axon buton and the muscle
excitability
muscle fibers stimulated by nerve impulses
extensibilty
muscle fiber ability to stretch beyond their relaxed, anatomical length
elasticity
muscle fibers ability to return to shape after stretch/contraction
isotonic contraction
“typical” skeletal muscle contraction where muscle shortens and movement occurs
Ex. bending knee, smiling, rotating arm
isometric contraction
“rare”
muscle engaged but not shortened (no contraction)
Ex. pushing a wall, muscle vs. immovable object
tetanic contraction
when muscle must sustain contraction because no chance to rest
Ex. carrying boxes down stairs
Tonus contraction
muscles that are in a constant state of partial contraction (muscle tone)
about 10% of fibers are contracted on a rotating basis
Ex. back muscles (even when sleeping), occipitalis (holds scalp down)
keeps muscles in an optimal length ready for action
involuntary
If the sarcomeres are less than 60% or more than 175% of their optimal length?
develop no tension in response to stimulus because there’s either too much overlap for movement or too little to grip