Muscle Physiology: Flashcards
Re Muscle Physiology
T/F After depolarization of the nerve, AP travels up to the terminal button of the axon
True
Re Muscle Physiology
As AP reaches the terminal bouton it opens up voltage gated ______ channels
Calcium channels
Re Muscle Physiology
The synaptic vesicles fuse releasing _____ to the synaptic cleft
Ach
Re Muscle Physiology
Acetylcholine diffuses to the synaptic cleft towards sk muscle binding to ____ _____ receptors
Nicotinic Ach receptors
Re Muscle Physiology
Binding of _____ to the receptors causes depolarization and muscle contraction
Ach
Ach is broken down by enzyme ________ terminating the action potential conduction
Acetyl-Cholinesterase enzyme
Depolarization of skeletal muscle membrane causes conduction of impulses down the _______
T Tubules
Conduction down the T tubules cause conformational change of the ________ receptor causing opening of ___________ receptor allowing _______ to pass
- Dihydro-pyridine
- Ryanodine receptor allows
- Calcium to pass
What is the effect of influx of extra-cellular Calcium to the skeletal muscle?
NONE; No role of extracellular calcium in Skeletal muscle
Calcium is from Sarcoplasmic Reticulum
Intracellular calcium increases, calcium binds to trop _______ causing Trop ______ to expose the myosin-binding site causing cross bridge cycling
Trop C
Trop I
In cross bridge cycling, at first myosin is bound to actin, ______ is needed to release the binding
ATP
When ATP binds to myosin it is released from ______
Actin
ATP is hydrolyzed to ADP + P producing a ____ energy cocked state
HIGH
Myosin then binds to actin and causes a power stroke after complete _______ of ATP
Hydrolysis
As long as _____ remains bound to Troponin C, Myosin remains bound to actin until another ATP binds
Calcium
