Muscle & Nerve Disease Flashcards
investigations in muscle and nerve disease?
history and exam creatine kinase EMG muscle biopsy genetics
structural?
muscular dystrophies
contractile?
congenital myopathies
coupling?
channelopathies
energy?
enzymes + mitochindria
what happens in myasthenia gravis?
NMJ disorder
Antibody blocks Ach receptors preventing binding
relapsing remitting disease
clinical presentation in myasthenia gravis?
fatiguable and weakness
- eyes (ptosis), limbs, muscles mastication, SOB, diplopia
symptoms often progress over the day as they get weaker
Investigations in myasthenia gravis?
AChR antibody
Anti-MuSK ab
Neurophysiology
CT chest (thymoma)
treatment in myasthenia gravis?
anti cholinesterase
immunosuppresion
Peripheral nerve consists of? (4)
sensory axons
motor axons
autonomic axons
nerve sheath (myelin)
causes of peripheral neuropathy?
hereditary metabolic toxic infectious - lyme, HIV, leprosy malignancy inflammatory demyelinating - Gullain Barre Syndrome
symptoms in nerve root?
myotome wasting
weakness
reflex change
sensory change
symptoms in individual nerve?
wasting and weakness of innervated muscle
specific sensory changes
symptoms in generalised peripheral neuropathy?
sensory and motor symptoms usually starting distal and moving proximal
Main points in Guillain-Barre Syndrome?
rapid onset of muscle weakness beginning in the feet and hands, changes in sensation and weakness
numbness/pins and needles/weakness/pain/balance and co-ordination problems
