Muscle 3 Flashcards
What is IL-15?
Myokine released during muscle contractions
What does IL-15 do?
Increases muscle glucose uptake and lowers the rate of contractile protein deterioration
What are the benefits of IL-15?
Increases myoblast differentiation, decreases protein degradation, increases protein synthesis
What does IL-15 do to the diaphragm?
Increasing force producing capacity and preserves musculature
What is poloxamer-188?
Synthetic, non ionic, nontoxic block copolymer surfactant
What does poloxamer-188 do?
Plugs holes in torn membranes to prevent muscle damage and boost repair
What are heat shock proteins?
Molecular chaperones involved in protein folding
When are heat shock proteins released?
In response to stress
What happens to SERCA at high temps when Hsp70 is absent?
Reduced activity
What happens when Hsp70 is overexpressed?
Amelioration of dystrophic pathophysiology
What does BGP-15 do?
Improves SERCA activity, pathology, calcium uptake and survival (24%)
What muscle did BGP-15 reduce fibrosis in?
Tibialis anterior
Does BGP-15 have an affect in older mice?
No improved muscle function
What is tranilast?
Orally bioavailable anti-allergic approved for human use
What does tranilast do?
Decreased fibrosis 31% in diaphragm of mdx mice but this did not translate to improve specific force
