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Neurologic Conditions > Multiple Sclerosis > Flashcards

Multiple Sclerosis Flashcards

1
Q

Who is MS MC in?

A

Young adult whilte females (12-50yo)

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2
Q

Where is MS MC?

A

Northern latitude & greater the farther from the equator

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3
Q

How do 70% of MS pts begin?

A

Relapsing-remitting MS

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4
Q

What is the duration of exacerbations or relapses?

A

Always >24 hours & average wks to mo & then spon gradually improve or resolve

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5
Q

How many exacerbations do new pt experience in the 1st year?

A

1-3

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6
Q

What do subsequent exacerbations usually implicate?

A

Different area of CNS disturbance

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7
Q

How can an exacerbation present?

A

Acute or subacute

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8
Q

What are the MC presenting exacerbations in MS?

A
  • Parasthesia, us unilateral
  • Optic neuritis
  • Transverse Myelitis (LC than paraparesis)
  • Vertigo
  • Diplopia
  • Ataxia
  • Facial pain
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9
Q

What is Optic neuritis?

A

Monocular visual decrease

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10
Q

What is Transverse Myelitis?

A

Focal weakness at 1 limb or 1 side

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11
Q

What is the sensory disturbance distribution?

A

Usually not in distribution of a peripheral nerve

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12
Q

What is the weakness type?

A

UMN type & never of a single muscle

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13
Q

What is the cause of monocular visual decrease?

A

Retro-orbital

Optic disc may be inflamed

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14
Q

What is the most sensitive imaging for MS?

A

MRI w/ & w/o contrast

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15
Q

Where are MS plaques found?

A

Anywhere in the white matter of bain or myelinated SC

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16
Q

The ____ ____ is unaffected by MS.

A

Peripheral nervous system

17
Q

____ ____ occur in~90% & once + remain in the ___.

A

CSF ABN

Pons

18
Q

What are the CSF ABN of MS?

A
    • Oligoclonal bands
    • IgG index
    • IgG synthesis rate
19
Q

What is MS?

A

AI dz that targets the oligodendrocyte

20
Q

What are the dz modifying drugs?

A
  • Beta-interferons
  • Glatiramer acetate (Copaxone)
  • Anti-monoclonal Ab agents natalizumab (Tysabri)
  • Fingolimod
  • Mitoxantrone (2ndary progressive MS)
21
Q

What is the management of MS?

A
  • Corticosteroids
  • Antispastic agents
  • Agents for bladder spasticity
  • Antidepressants
22
Q

What are corticosteroids used for?

A

Shorten length of exacerbations

Neurologic Conditions (15 decks)

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