Multiple Endocrine Neoplasia

Question 1

What are the main types of MEN?

Answer 1

MEN type I
MEN type IIa
MEN type IIb

Question 2

What is MEN1 due to?

Answer 2

MEN1 gene

Question 3

What are the features of MEN1?

Answer 3

3P’s
Parathyroid
Pituitary
Pancreas

Question 4

What does parathyroid involve?

Answer 4

Hyperparathyroidism due to parathyroid hyperplasia

Question 5

What does pancreas include?

Answer 5

Insulinoma
Gastrinoma- leading to recurrent peptic ulceration

Question 6

What 3 features would indicate MEN1?

Answer 6

Peptic ulceration, galactorrhoea
hypercalcaemia

Question 7

What is MEN2 due to?

Answer 7

Mutation in the RET gene

Question 8

What is affected by MEN2a?

Answer 8

Thyroid:
Adrenal
Parathyroid

Question 9

What are the main features of MEN2a?

Answer 9

Medullary thyroid cancer
Pheochromocytoma
Parathyroid hyperplasia or adenomas

Question 10

What are the features of MEN2a?

Answer 10

2 P’s

Question 11

What is MEN2b due to?

Answer 11

Mutation of the RET gene

Question 12

What are the features of MEN2b?

Answer 12

1 P

Question 13

What are the presenting features of MEN2b?

Answer 13

Thyroid: medullary thyroid cancer
Adrenal: pheochromocytoma
Parathyroid: hyperplasia/adenomas
Mucosal neuromas