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Endocrine > Acromegaly > Flashcards

Acromegaly Flashcards

1
Q

What is acromegaly?

A

It is the clinical manifestation of excessive growth hormone

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2
Q

What produces growth hormone?

A

Anterior pituitary

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3
Q

What does growth hormone act on?

A

The liver to produce IGF-1

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4
Q

What does IGF-1 cause?

A

Excessive bone and soft tissue growth

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5
Q

What are the causes of acromegaly?

A

Pituitary adenoma

Ectopic GHRH or GH from pancreatic tumour

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6
Q

What is the presentation of acromegaly?

A

Headaches
Coarsening of facial features
Shoes no longer fit
Spade like hands

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7
Q

Why might the patient present with excessive sweating and oily skin?

A

Due to hypertrophy of the sweat gland

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8
Q

What signs would there be if the Acromegaly was caused by a pituitary tumour?

A

Bitemporal hemianopia
Hypopituitarism
Headaches

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9
Q

What are 2 important signs of Acromegaly?

A

Skin tags

Profuse sweating

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10
Q

What is the main test for Acromegaly?

A

Serum IGF-1

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11
Q

What is serum IGF-1 used for?

A

To test for Acromegaly

To monitor Acromegaly

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12
Q

What is used to confirm the diagnosis of Acromegaly?

A

Oral glucose tolerance test

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13
Q

Why would you do an MRI in Acromegaly?

A

For a pituitary adenoma

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14
Q

What is the management of acromegaly?

A

Trans-sphenoidal surgery

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15
Q

What would you give a patient not suitable for surgery?

A

Somatostatin analogue

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16
Q

What somatostatin analogue would you give a patient?

A

Octreotide

17
Q

What other drugs can you give for Acromegaly?

A

Pregvisomant

Bromocriptine

18
Q

What type of drug is Pregvisomant?

A

GH receptor antagonist

19
Q

What type of drug is Bromocriptine?

A

Dopamine agonist

20
Q

What are the possible complications of Acromegaly?

A

Obstructive sleep apnoea
Type 2 diabetes
Arthritis
Hypertension

21
Q

What heart problem is a complication of acromegaly?

A

Cardiomyopathy- Left ventricular hypertrophy

Endocrine (27 decks)

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