Multi-step Tumourigenesis Flashcards
1
Q
How does tumour formation progress?
A
Occurance of consecutive dyregulation events.
CRC 3+ TSG deativations and 1 Oncogene activation
2
Q
What is the difference between the Darwinian Evolution Model and Silver Spoon Model?
A
DEM assumes all cells are equally capable of generating cancerous cells, but SSM suggest that some “cancer stem cells” are more capable of producing cancerous cells.
3
Q
What is the idea of intraturmoural heterogeneity?
A
In a tumour, due to genomic instability there is a tremendous amount of genetic diversity between cells. Higher chance of reaching required mutations for metastatic cancers.
4
Q
What are the two classes of carcinogens?
A
Promoters and initiators
