First 3 pillars of Cancer Management Flashcards

1
Q

What is brachytherapy?

A

Internal radiotherapy where threads, seeds or capsules containing radiation sources are placed within the body

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2
Q

What is oncogene addiction?

A

Dependency of certain tumour cells on a single activated oncogenic protein or pathway to maintain malignant properties

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3
Q

What is the cause of Chronic Myeloid Leukemia (CML)?

A

Philadelphia chromosome

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4
Q

What is the difference between chemotherapy and targetted therapy?

A

Chemotherapy targets the capacity to replicate DNA that all cells have. Targetted therapies target a specific oncogene- less side effects

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5
Q

What class of cytotoxics can be used to treat paediatric leukaemia and lymphomas?

A

Antimetabolites, aminopterin- Antagonist of folate metabolism, inhibits the formation of tetrahydrofolate. DNA and RNA synthesis inhibitor

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6
Q

What does paclitaxel do?

A

Blocks the breakdown of microtubules

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7
Q

What is the mechanism of action of Cis-platin?

A

Generates covalent cross links within DNA and intra-strand crosslinks

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