Metastasis I Flashcards
1
Q
How do tumours kill?
A
Impair organ function
Cascade multi-organ failure
2
Q
What type of cells causes the most life threatening cancers?
A
Carcinomas from epithelial tissues
3
Q
What prevents a benign neoplasm from being malignant?
A
Basement membrane
4
Q
What are common arrest sites for circulating tumour cells?
A
Lungs, brain and bone
5
Q
How do tumours errode the basement membrane to achieve metastasis?
A
Using matrix metalloprotinases (MMPs)
6
Q
How is epithelial to mesenchymal transition (EMT) defined?
A
Switch from E-Cadherin expression to N-Cadherin expression.
N-N a lot weaker so promotes migration and binding
7
Q
What is organotropism?
A
The idea that different tumours establist metastases in specific organs.
