MSRA: Ovarian Cysts & Cancer

Question 1

What are the risk factors for ovarian cancer?

Answer 1

Increasing age
Family history
Genetics: BRCA1,2 and Lynch syndrome
Nulliparity

Question 2

What is the inheritance pattern of the BRCA gene mutations?

Answer 2

Autosomal dominant

Question 3

What are the three components of the risk of malignancy index?

Answer 3

Menopausal status
Ultrasound features
CA-125 measurement

Question 4

What are the worrying features of an ovarian cyst in a post-menopausal woman?

Answer 4

> 5cm, complex, symptomatic

Question 5

When should tumour markers be measured in a pre-menopausal woman?

Answer 5

Measure LDH, bHCG and aFP if under 40 with a complex ovarian mass
(Probability of germ cell tumour)

Question 6

What are the features of Meig’s syndrome?

Answer 6

Δ Benign ovarian tumour (fibroma), ascites and pleural effusion

Question 7

What is the most common ovarian cyst type?

Answer 7

Follicular cyst

Question 8

What is the most common type of ovarian cancer?

Answer 8

Serous