MSK Spasticity Flashcards
Baclofen - antispastic/spasmolytic, brand name, MOA, AR’s, route of admin
antispastic
lioresal
GABAb agonist, facilitates spinal inhibition of motor neurons (inhibits reflexes)
temporary drowsiness, confusion, hallucinations (CVA or elderly), nausea, weakness, headache
oral, intrathecal (btwn brain and SC)
Chlorzoxazone - antispastic/spasmolytic, brand name, MOA, AR’s, route of admin
parafon forte
Cyclobenzaprine - antispastic/spasmolytic, brand name, MOA, AR’s, route of admin
spasmolytic
flexeril
Poorly understood inhibition of mus stx reflex in SC
drowsiness, dizziness, nausea, lightheadedness, vertigo, ataxia, headache, tolerance and physical dependence
hepatic metabolism ~4-6 hrs
Dantrolene - antispastic/spasmolytic, brand name, MOA, AR’s, route of admin
antispastic
dantrium
blocks RyR1-Ca2 release channels in sarcoplasmic reticulum of skeletal mus
(inhibits Ca release and mus contraction)
generalized weakness, severe hepatotoxicity and fata hepatitis
IV, oral
Diazepam - antispastic/spasmolytic, brand name, MOA, AR’s, route of admin, antidote for OD
valium
facilitates GABAergic transmission in CNS
sedation, reduction in psychomotor ability, dependence, OD can lead to coma or death
hepatic metabolism ~12-24 hrs
flumazenil
Tizanidine - antispastic/spasmolytic, brand name, MOA, AR’s, route of admin
antispastic
zanaflex
alpha-2 adrenoreceptor agonist in SC (reduces spasticity by increasing presynaptic inhibition)
renal and hepatic elimination
dry mouth, sedation, dizziness, less weakness than oral Baclofen and Diazepam
Metaxalone - antispastic/spasmolytic, brand name, MOA, AR’s, route of admin
***chart said this drug is like cyclobenzaprine w/ varying degrees of antimuscarinic effect
skelaxin
Poorly understood inhibition of mus stx reflex in SC
toxicities - strong antimuscarinic effects (ex. dry mouth, blurred vision, urinary retention, constipation)
hepatic metabolism ~4-6 hrs
