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561 > Autonomic Pharm > Flashcards

Autonomic Pharm Flashcards

1
Q

MOA and clinical use of atropine

A

MOA: competitive antagonist at muscarinic receptors (M1-M5)

Clinical: treat bradycardia; ophthalmic exams; antidote for cholinergic poisoning

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2
Q

MOA and clinical use of scopolamine

A

MOA: competitive antagonist at muscarinic receptors (M1-M5)

Clinical: motion sickness; post-op nausea

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3
Q

MOA and clinical use of ipratropium bromide or tiotropium bromide

A

MOA: competitive antagonist at muscarinic receptors (mainly M3)

Clinical: COPD, asthma (bronchodilation)

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4
Q

MOA and clinical use of oxybutynin or tolterodine

A

MOA: competitive antagonist at muscarinic receptors (mainly M3)

Clinical: overactive bladder

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5
Q

MOA and clinical use of benztropine

A

MOA: competitive antagonist at muscarinic receptors

Clinical: PD (decreases tremor and rigidity)

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6
Q

MOA and clinical use of tropicamide

A

MOA: competitive antagonist at muscarinic receptors

Clinical: ophthalmic exams (dilate pupils)

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7
Q

MOA and clinical use of dicyclomine

A

MOA: competitive antagonist at muscarinic

Clinical: irritable bowel syndrome (IBS)

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8
Q

MOA and clinical use of hyoscyamine

A

MOA: competitive antagonist at muscarinic receptors

Clinical: GI disorders (cramps)

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9
Q

Bethanechol - Direct/non-direct cholinergic agonist, MOA, AE

A

direct-acting

MOA/pharm: Increase tonicity in detrusor musc and stimulate gastric motility

abdominal discomfort, urinary urgency, flushing of skin, bronchial constriction, asthma attacks

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10
Q

Pilocarpine - Direct/non-direct cholinergic agonist, MOA/pharm effect, AE

A

direct

PE: decreases fluid in eye which decreases pressure in eye

blurred vision, decreased night vision, eye irritation, headache, increase sweating and salivation

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11
Q

Methacholine - direct/indirect cholinergic agonist, used for

A

direct

dx asthma

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12
Q

Carbachol - direct/indirect cholinergic agonist, used for

A

direct

tx glaucoma

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13
Q

Phenylephrine (adrenergic, alpha 1 agonist) - pharm effect, MOA, AE

A

decreases nasal congestion

stimulates adrenergic receptors

increased BP, headache, slow HR

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14
Q

Pseudoephedrine (adrenergic, alpha 1 agonist) - pharm effect, MOA, AE

A

decreases nasal congestion

stimulates adrenergic receptors

increased BP, headache, slow HR

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15
Q

Oxymetazoline (adrenergic, alpha 1 agonist) - pharm effect, MOA, AE

A

decreases nasal congestion and eye redness

stimulates adrenergic receptors

increase BP, low HR, headache

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16
Q

xylometazoline (adrenergic, alpha 1 agonist) - pharm effect, MOA, AE

A

decreases nasal congestion

stimulates adrenergic receptors

headache, increase BP, slow HR

17
Q

Clonidine and methyldopa (adrenergic, alpha 2 agonist) - MOA/PE, AE

A

antihypertensive agent

dizziness, drowsiness, dry mouth

18
Q

Dobutamine (andrenergic, beta 1 agonist) - PE, AE

A

increases force of cardiac contraction

chest pain, arrhythmias, SOB or difficulty breathing

19
Q

Dopamine (andrenergic, beta 2 agonist) - PE, AE

A

CHF

chest pain, arrythmias, SOB or difficulty breathing

20
Q

Albuterol (andrenergic, beta 2 agonist) - PE, AE

A

bronchodilation in asthma pts

nervousness, restlessness, trembling

21
Q

Salmeterol (andrenergic, beta 2 agonist) - PE, AE

A

bronchodilation for asthma pts

nervousness, restlessness, trembling

22
Q

Terbutaline (andrenergic, beta 2 agonist) - PE, AE

A

delay preterm labor (slow contractions of uterus)

nervousness, restlessness, trembling

23
Q

Amphetamine (non-selective adrenergic) - PE, AE

A

tx ADD in children and narcolepsy

CNS excitation, HTN, anxiety, arrhythmias

24
Q

Epinephrine (non-selective adrenergic) - PE, AE

A

anaphylactic shock (extreme allergic rxn)

CNS excitation, HTN, anxiety, arrhythmias

25
Q

Norepinephrine (non-selective adrenergic) - PE, AE

A

hypoTN during shock

CNS excitation, anxiety, HTN, arrhythmias

26
Q

adrenergic Alpha 1 antagonists
-osin

prazosin and doxazosin PE, AE

A

antiHTN

reflex tachycardia, orthostatic hypoTN, dizziness

27
Q

adrenergic Alpha 1 antagonists
-osin

alfuzosin and tamsulosin PE, AE

A

tx urinary retention and symps of benign prostatic hyperplasia

reflex tachycardia, orthostatic hypoTN, dizziness

28
Q

adrenergic Alpha 1 antagonists
-osin

**phenoxybenzamine PE, AE

A

control BP before and during removal of pheochromocytoma (cancer of adrenal gland)

reflex tachycardia, dizziness, orthostatic hypoTN

29
Q

adrenergic beta selective 1 antagonists
-olol

atenolol PE, AE

A

tx of HTN and chronic stable angina

bronchoconstriction, increase airway resistance, bradycardia, dizziness, depression, lethargy

30
Q

adrenergic beta selective 1 antagonists
-olol

bisoprolol and metoprolol PE, AE

A

tx HF

bronchoconstriction, increase airway resistance, bradycardia, dizziness, depression, lethargy

31
Q

adrenergic beta selective 1 antagonists
-olol

esmolol PE, AE

A

tx arrhythmia during surgery

bronchoconstriction, increased airway resistance, bradycardia, dizziness, depression, lethargy

32
Q

adrenergic non-selective blockers (beta 1 and 2) antagonists
-olol

propranolol PE, AE

A

tx HTN and migraine

bronchoconstriction, increased airway resistance, bradycardia, dizziness, depression, lethargy

33
Q

adrenergic non-selective blockers (beta 1 and 2) antagonists
-olol

timolol PE, AE

A

tx glaucoma

bronchoconstriction, bradycardia, increased airway resistance, dizziness, depression, lethargy

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