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Medicine > MSK case > Flashcards

MSK case Flashcards

1
Q

Functions of the musculoskeletal system: (6)

A
  • Protects organs
  • Stores and releases fat
  • Produces blood cells
  • Stores and releases minerals
  • Facilitates movement
  • Supports the body
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2
Q

Mineral phase of bone:

A
  • Hydroxyapatite (a calcium phosphate)
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3
Q

Organic phase of bone:

A
  • Collagen and other proteins
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4
Q

Bone cells: osteochondral progenitor cells

A
  • Undifferentiated stem cells
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5
Q

Bone cells: Osteoblasts

A
  • Make new bone
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6
Q

Bone cells: osteocytes

A
  • Maintain the activity of the bone
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7
Q

Bone cells: Osteoclasts

A
  • Reabsorb (remove) bone
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8
Q

Types of bone: (2)

A
  • Cortical bone

- Trabecular bone

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9
Q

Bone and calcium:

  • Role of bones
  • Amount of calcium
A
  • Bone is the main body store of calcium

- Body contains approximately 1Kg of calcium and 99% of that is bone

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10
Q

Calcium regulation: Parathyroid hormone

  • Secretion
  • Action on kidney :Ca, Ph, VitD
  • Action on bone
A
  • Secreted from the parathyroid glands
  • Actions on the kidney:
    . Increases Ca Resorption in distal tubules
    . Increases Phosphate excretion
    . Increases formation of active vitamin D
  • Actions on bone:
    . Stimulates bone Resorption
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11
Q

Vitamin D sources:

A
  • Mostly formed from the action of UV light on the skin
  • Also found in some foods (oily fish)
  • Highly fat soluble, large amounts stored in the adipose tissue
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12
Q 
Vitamin D activation pathway:
- 2 Reactions
- Liver: cholecalciferol to .....
- Kidney: ...... to active vit D
Regulated by the enzyme:
A
  • 2 hydroxylation reactions
  • In the liver:
    Cholecalciferol to calcidiol
  • In the kidney:
    Calcidiol to active vitamin D
  • regulated by the enzyme 1a-hydroxylase
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13
Q

Actions of vitamin D:

  • Bone
  • Intestine (Ca,Ph)
A
  • Bone: stimulates bone resorption
  • Intestine:
    . Stimulates calcium absorption
    . Stimulates phosphate absorption
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14
Q

Calcitonin:

  • Secretion
  • Effect
A
  • Secreted by parafollicular cells of the parathyroid gland

- Opposes the effect of PTH

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15
Q

Regulation of low calcium levels:

A
  • Parathyroid gland releases PTH

- Calcium levels increase

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16
Q

Bone density:

A
  • A measure pf the amount of minerals present in the bone
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17
Q

Factors effecting bone density: (3 main)

A 
- Availability of substrates
. Ca intake, Ca absorption, PTH functionality  
- Physiological factors
. Exercise, BMI, smoking
- Biochemical factors
. Hormones
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18
Q

Groups that require calcium supplementation:

A
  • Vegans

- Lactose intolerance

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19
Q

Bone density after menopause:

A
  • Decreases
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20
Q

Macroscopic bone structures: (2)\

  • Axial
  • Apendicular
A
  • Axial: skull, spine, ribs

- Appendicular: Limbs, pelvis, shoulders

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21
Q

Osteology:

  • E
  • M
  • D
A
  • Epiphysis: ends of the long bone
  • Metaphysis: Wide part of the bone. Growth occurs here
  • Diaphysis: long part of the bone (shaft)
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22
Q

Cortical bone: (4)

  • Type
  • Skeletal weight %
  • Organisation
  • Turnover rate
A
  • Compact bone
  • 80% skeletal weight
  • Organised into Haversian systems
  • Slow turnover
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23
Q

Cancellous bone: (5)

  • Type
  • Density
  • Wolff’s law
  • Turnover rate
  • Function
A
  • Spongy/trabecular
  • Less dense
  • Remodels due to Wolff’s law
  • High turnover
  • Haematopoiesis
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24
Q

Haematopoiesis:

A
  • The formation of bloods cellular components
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25
Q

Osteoblast products:

A
  • Type 1 collagen
  • ALP - initiates calcification
  • Calcium phosphate
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26
Q

Osteocytes further:

  • Positioning
  • Derivation
  • Causes
A
  • Lie within lacunae in mature bone
  • Derived from osteoblasts
  • Responsible for bone maintenance
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27
Q

Wolff’s Law:

A
  • Bones will adapt based on the stress or demands placed on them
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28
Q

Primary bone healing: (2)

A
  • Absolute stability + compression

- No callus

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29
Q

Secondary bone healing:

A
  • Relative stability

- Callus formation

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30
Q

Stages of bone break/heal: (5)

A
  • Fracture
  • Haematoma forms: blood surrounds the fracture, inflammatory cells arrive
  • Soft callous: repairing stage. Osteoblasts arrive, forming new unmineralised bone
  • Hard callous: soft callous becomes mineralised due to calcification
  • Remodelling
31
Q

Stages of bone healing: haematoma

A
  • Blood surrounds the fracture, inflammatory cells arrive, causing inflammation
32
Q

Stages of bone healing: soft callous

A
  • Osteoblasts form new uncalcified bone around the fracture.
33
Q

Stages of bone healing:hard callous

A
  • Soft callous is calcified
34
Q

Stages of bone healing: remodelling

A
  • 12-18 months for the bone to revert to its original shape without surgery.
35
Q

Factors influencing bone healing: (2)

- Variables

A
  • Fracture variables

- Patient variables

36
Q

Fracture variables: (3)

A
  • Blood supply
  • Complexity
  • Immobilisation
37
Q

Patient variables: (5)

A
  • Nicotine
  • Diabetes mellitus
  • Diet/deficiencies
  • COX-2 inhibitors
  • HIV
38
Q

Functions of skeletal muscle (4)

A
  • Movement
  • Control posture
  • Remove and store glucose
  • Generate heat (temp. regulation)
39
Q

Sarcomere:

A
  • Distance between two z lines
40
Q

Striations:

  • I band
  • A band
  • Which band shortens
A
  • I band: appears light
  • A band: appears dark
  • The I band appears to shorten
41
Q

Isotonic movement:

A
  • muscle resists a constant weight, changing length in the process
42
Q

Isometric movement:

A
  • Contraction under tension, muscle doesn’t change length
43
Q

An action potential is:

A
  • A regenerating depolarisation of membrane potential that propagates along an excitable membrane
44
Q

Excitatory synapses: (4)

A
  • AP in pre-synaptic cells causes a release of vesicles
  • Transmitter diffuses to receptors on post-synaptic cell.
  • Activation of receptors depolarises (via Na+ entry) cell to threshold
  • Initiating AP in post-synaptic cell
45
Q

Neuromuscular Junction (NMJ) structure: - Active zones:

  • Top of cleft
  • Bottom of cleft
A
  • Aligned with clefts in the post-junctional membrane
  • Top of the clefts = nACH receptors (minimal diffusion distance)
  • Bottom of clefts = voltage-gated Na+ channels (distance unimportant)
46
Q

Concentric contraction:

A
  • shortening of the muscle during contraction
47
Q

Eccentric contraction:

A
  • Lengthening of the muscle during contraction
48
Q

Skeletal muscle relaxants: (3)

  • B T
  • C
  • S
A
  • Botulinum toxin: Prevents release of Ach-containg vesicles (muscle paralysis)
  • Curare: blocks nAChrRs to cause paralysis
  • Succinylcholine: short-acting block of nAChR
49
Q

Sarcoplasmic reticulum (SR) and T tubules:

A
  • SR is a Ca store
  • T tubules conduct AP into the muscle fibre
  • T tubule AP stimulates Ca release from the SR, stimulates contraction
50
Q

Functions of the SR: (3)

A
  • Stores calcium
  • Rapidly releases calcium (AP triggered)
  • Rapidly restores calcium (using ATP-driven calcium pumps)
51
Q

T tubule function:

A
  • To convey quickly the action potential deep inside the fibre
52
Q

Triad:

A
  • A t tubule and two SR’s
53
Q

Membrane receptors in triads: (2)

  • voltage sensor:
  • Ca release channel
A
  • DHP receptors: voltage-sensors

- Ryanodine receptors: calcium release channels

54
Q

Tetanic contraction:

A
  • At high rates of stimulation, no muscle relaxation is seen (fused)
55
Q

How to measure osteoblastic activity:

A
  • The enzyme alkaline phosphate acts as a marker
56
Q

Development of the wrist:

A
  • As the skeletal system matures, carpal bones ossify

- Becoming visible on radiographs, this allows for an estimation of age

57
Q

Torus fractions:

A
  • The bone buckles, but the integrity of the surface of the bone on the convex side is maintained
  • The bone will remodel over time
58
Q

Greenstick fracture:

A
  • Usually mid-diaphysial

- Damage to convex surface but fracture is incomplete

59
Q

Growth plate fractures:

A
  • Salter Harris fractures

- 5 types

60
Q

Type 1 SHF:

A
  • SLIPPED

- Shift between epiphysis from the metaphysics

61
Q

Type 2 SHF:

A
  • ABOVE

- Fracture extends through meta-physis and physis

62
Q

Type 3 SHF:

A
  • LOWER

- Fracture extends through from the physis to the epiphysis

63
Q

Type 4 SHF:

A
  • THROUGH/TRANSVERSE

- Fracture passes through the physis, epiphysis and metaphysics

64
Q

Type 5 SHF:

A
  • RAMMED/RUINED

- Physis is crushed

65
Q

Rickets causes: (4)

A 
- Causes:
. Prematurity
. Nutrition
. Maternal vit D deficiency 
- Lack of sunlight
66
Q

Rickets symptoms:

A
  • Skeletal changes

- Growth pains

67
Q

Osteopenia:

A
  • Reduced bone mineral density

- Without differentiating between reduced BDM and oesteroperosis

68
Q

Effects of age on bone: (3)

A
  • Resorption greater than formation

- Osteoporosis

69
Q

Sarcopenia:

A
  • Accelerated loss of muscle mass and function
70
Q

Acute pain:

  • Duration
  • Aetiology
  • Purpose
  • MSK examples
A
  • Short
  • Result of injury or disease
  • Important protective role
  • Fracture, sprains
71
Q

Chronic pain:

  • Duration
  • Aetiology
  • Purpose
  • MSK examples
A
  • Long (>3-6 months)
  • Can be related or unrelated to tissue damage
  • None
  • Chronic back pain, osteoarthritis
72
Q

Stress definition:

- Physiological changes

A
  • A state of disharmony or a threat to homeostasis

- Alertness, focus and energy

73
Q

Endochondral ossification steps (5)

  1. ……. Cells differentiate into ……., forming a cartilage model
  2. central ….. undergo ….. altering the matrix they secrete, enabling ……
  3. ….. undergo …….., blood vessels invade bringing ……
  4. Primary ….. centre forms in the centre …….
  5. Secondary…..
A
  1. Begins in utero Mesenchymal cells differentiate into chondrocytes, forming a cartilage model for the bone
  2. Central chondrocytes undergo hypertrophy, altering the matrix they secrete, enabling mineralisation
  3. Chondrocytes undergo apoptosis, blood vessels invade, bringing osteogenic cells
  4. Primary ossification centre forms in the centre, increasing bone width
  5. Secondary ossification centres form at epiphyseal regions after birth
74
Q

Intramembranous ossification:

  • Steps (5)
    1. Mesenchymal cells differentiate into……
    2. Osteoblasts become entrapped by the …..
    3. ….. bone and ….. form
    4. ……. bone forms superficial to ……
    5. Blood vessels form the ………
A
  1. Mesenchymal cells differentiate into osteoblasts and group up (ossification centres)
  2. Osteoblasts become entrapped by the osteoid they secrete, making them osteocytes
  3. Trabecular bone and periosteum form
  4. Cortical bone forms superficial to trabecular bone
  5. Blood vessels form the red marrow

Medicine (18 decks)

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