MSK Flashcards
What is tenosynovitis
- Inflammation of the fluid-filled sheath that surrounds a tendon
- Typically leading to joint pain, swelling, and stiffness
In osteomyelitis for how long does an X-ray remain normal looking
The first 10-14 days
Regarding osteomyelitis:
- Good disc = ?
- Bad disc = ?
- Good disc = Bad news (tumour)
- Bad disc = Good news (infection)
Define ankylosis
Joint stiffness due to abnormal adhesion and rigidity of the bones of the joint
Describe the antibiotic part of ortho TB treatment
- Initially = Rifampicin, Isoniazid, Ethambutol for 8 weeks
- Then = Rifampicin + isoniazid for 6-12 months
what disease activity score = clinical remission and what score = eligibility for biologic therapy
- DAS <2.4 = clinical remission
- DAS >5.1 = eligibility for biologic therapy
Outcome of RA
- Life expectancy shortened by ~7 years
- 50% out of workplace within 2 years of diagnosis
Describe the function of the normal synovium
- Maintenance of intact tissue surface
- Lubrication of cartilage
- Control of synovial fluid volume + composition
- Nutrition of chondrocytes within joints
4 types of OI
- Type 1 = Milder form, presents when child starts walking (can be present in adults)
- Type 4 = Similar to type 1 but more severe
- Type 11 = Lethal by age 1
- Type 111 = Progressive deforming with severe bone dysplasia + poor growth
Treatment of osteoporosis
- Bisphosphonates (oral) (first line)
- Parathyroid Hormone Analog (teriparatide)
- Monoclonal antibody against RANK ligand (Denosumab)
- HRT
- Selective oEstrogen Receptor Modulator (SERM)
Why use denosumab and how is it taken
- Subcutaneous injection every 6 months
- Safer in patients with significant renal impairment than bisphosphonates
What is enthesitis
Inflammation of the entheses, the sites where tendons or ligaments insert into the bone.
What is sacroiliitis
- Inflammation within one, or both, of the sacroiliac joints
- Causes prolonged, inflammatory pain in the lower back region, hips or buttocks
What does DMARDs stand for
Disease-modifying antirheumatic drugs
What is dactylitis
Inflammation of an entire digit (AKA sausage digit)