MS / ALS Flashcards

1
Q

3 characteristics of MS

A

chronic
autoimmune
demyelination –> plaques in CNS white matter

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2
Q

why does myelin matter? what do you see with demyelination?

A

myelin allows transfer of nervous signal through body

without it = stop or slow impulse

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3
Q

Trur of False:

with MS once you lose myelin its gone forever

A

False

remyelination can occur but is *incomplete *

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4
Q

which cells cause demyelination with MS

A

Th-cells and B-cells

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5
Q

4 types of MS

A
  1. Relapsing Remitting MS (RRMS)
  2. Primary Progressive MS (PPMS)
  3. Secondary Progressive MS (SPMS) (combine 1 and 2 types)
  4. Progressive Relapsing
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6
Q

match with the type of MS

-S&S develop and resolve over weeks to months
-Flare that Returns to baseline
-Most cases MS

A

Relapsing Remitting MS (RRMS)

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7
Q

match with the type of MS

-Small percentage
-Frequent relapse with partial recovery
-NO return to baseline

A

progressive relapsing

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8
Q

match with the type of MS

  • no remission, no acute attacks
  • gradual progression
  • onset 40-60 years
A

Primary Progressive MS (PPMS)

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9
Q

type of ms:

Often begins as Relapsing Remitting then becomes Progressive

A

Secondary Progressive MS (SPMS)
(combine 1 and 2 types)

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10
Q

causes of MS + frequency

A

genetics, immune, enviro

women > men
cold areas

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11
Q

s/s of MS re: mobility changes

A

Tremor
Fatigue
Spasticity

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12
Q

s/s of MS re: muscle weakness

A

Dysarthria
Dysphagia
Gait disturbances
Flaccid or spastic bladder or bowel

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13
Q

s/s MS re: visual changes

A

Decreased visual acuity and perception
Nystagmus
Blurred vision
Double Vision

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14
Q

s/s of MS re: cognition changes

A

Inattention
Memory issues
Problem solving difficulties
Alteration in reasoning

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15
Q

general s/s of MS:

A

-pain
-mobility changes
-muscle weakness
-parasthesia
-visual changes
-cognition changes

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16
Q

3 main complications from MS

A
  1. infection (aspiration pneuminia, UTI)
  2. immobilty (OP/ pressure injury)
  3. Depression

-Dysphagia–> Aspiration pneumonia
-Bladder retention –> UTI and Urosepsis

17
Q

diagnostics for MS

A

-clinical presentation
-LP
-MRI
-EMG
-Evoked Potential Testing or Visual Evoked Response

18
Q

what is Evoked Potential Testing or Visual Evoked Response?

A

test for ms :
-Non-invasive
-Evaluates transmission along optic nerve pathway

19
Q

factors that can make MS worse

A

-Fatigue
-Stress
-Overexertion
-Temperature extremes (hot bath, shower, cold weather…)

20
Q

what concerns do we have with MS patient eating?

A

aspiration! assess for dysphagia

21
Q

interventions for MS are focused on…

A

-Prevent exacerbations
-Manage symptoms
-Optimize function
-Alter effects on immune system

aka keep from getting sick and improve quality of life

22
Q

what kind of exercise do people with MS need to avoid? what should they do?

A

AVOID : rigorous activity/exercise and hyperthermia

DO: ROM, stretching, rest, strengthening

23
Q

bladder interventions for MS

A
  • self-cath
  • bladder pacemaker
24
Q

SEE BOOK FOR SPECIFIC DRUG STUFF

A

hint hint… maybe ill remember to make cards for this later

25
general drug stuff for MS: what are we giving?
- NSAIDS - Immunomodulators - Interferon-beta - Antispasmodics -->Intrathecal Baclofen
26
characteristics of ALS
- chronic - progressive - fatal - lose control of voluntary muscle
27
2 types of ALS
- familial - sporadic (more common)
28
patho of ALS
JK its too complicated, i aint a doctor
29
cause of ALS
mystery genetics, enviro
30
s/s of ALS
-Uncontrollable laughing or crying -Fatigue -Muscle cramps -Muscle weakness and atrophy -Twitching -Stiff-clumsy gait -Dysarthria -Dysphagia -Abnormal reflexes
31
what systems does ALS not effect?
sensory or bladder | both of these effected in MS
32
top complications from ALS
1. death in 2-5 years 2. immbolity (falls, pressure injury) 3. Respiratory (trach/vent, bipap, failure, aspiration pneumonia )
33
diagnostics for ALS
by rule out - do all the usual neuro tests
34
interventions for ALS focused at ...
slow progression, optimize function, ensure comfort
35
special resp intervention for ALS that is placed in the client
Diaphragm Pacer - In ALS, diaphragm pacing is primarily intended to achieve muscle conditioning by taking advantage of the heterogeneous muscle involvement in this disease
36
drugs for als that increases life expectancy by 3-5 months
Riluzole (Rilutek)
37
other drugs for ALS (not sure if we need to know these?)
- Edaravone (Radicava)  IV agent. Effects unknown at this time. - Dextromethorphan and Quinidine Sulfate (Nuedexta) - Tiglutik (thickened Riluzole) - Exservan (Riluzole film)
38
ways to improve communication for ALS patients?
eye tracking boards, communication boards