Jacked up RBC Flashcards
this disorder is caused by abnormal platelet clumping in the small blood vessels
Thrombotic Thrombocytopenia Purpura (TTP)
This disorder has platelet antibobydies that destroy platelets in blood and spleen.
Autoimmune Thrombocytopenia Purpura (ATP)
P.S. the destruction occurs faster than production so you have a reduced platelet count
This disorder has platelet antibobydies that destroy platelets in blood and spleen.
Autoimmune Thrombocytopenia Purpura (ATP)
P.S. the destruction occurs faster than production so you have a reduced platelet count
This disorder is caused by unexplained platelet drop after herparin admin.
Heparin Induced Thrombocytopenia (HIT)
Give me the patho of whats happening in HIT
Heparin binds to platelet factor 4
–>activates platelets
–>Microclots
which of these is the only one that is autoimmune in nature and has antiplatelet antibodies:
TTP
ATP
HIT
Autoimmune Thrombocytopenia Purpura (ATP)
which of these results in destruction of platlets and which of these results in using up the platelets/reduction
TTP
ATP
HIT
destruction = ATP
reduction = TTP/ HIT
what do we use to treat HIT?
-stop heparin
-give argatroban ( Direct thrombin inhibitor?)
what do. we use to treat ATP?
- Immunosuppressants
- Chemo
- IV immunoglobulin
- IV Anti-Rho
- Splenectomy
what do we use to treat ATP?
Fatal if Untreated.
* Anticoagulants
* Platelet inhibitors
* Plasma Exchange
what do we use to treat ATP?
Fatal if Untreated.
* Anticoagulants
* Platelet inhibitors
* Plasma Exchange
which of these have microclots leading to ischemia?
TTP ATP HIT
TTP, HIT
you can have hit within ____ days of taking heparin
100
you can have hit within ____ days of taking heparin
100
assessment findings for thrombocytopenia
Bruises
Petechiae
Purpura
Mucous membrane bleeding
Anemia
assessment findings for thrombocytopenia are first seen where (general system)
skin and mucous membranes
in addition to microclots HIT also has risk of…
VTE/ PE
in addition to microclots HIT also has risk of…
VTE/ PE
intervention for anemia?
blood transfusion
platelets < ____ = platelet transfusion needed
10,000
platelets < ____ = risk for bleeding
platelets < ____ = risk for spontaneous bleeding
<50,000 = bleeding
<20,000 = sponatenous bleeding
surgical intervention for ATP?
splenectomy (no splenectomy for TTP or HIT)
post op splenectomy education/ risks
Infection prevention
Avoid crowds
When to contact MD for infection
