Mouse Reporting Questions Flashcards
What is DPC? How does it work?
days post coitus; staging by days
Presence of what is looked for to indicate start of DPC?
vaginal plug
Staging of mouse embryo development based one external/internal morphological changes of the embryo that may not be dependent on the age or size of mosue
Theiler
How many TS stages?
26
Why is mouse not good model organism?
Not exactly humanIn utero developmentComparatively large genome; there are organisms with more compact genomesLong gestation period compared to other model organismsEndocrinological, physiological, and environment influences cell functionLarge storage areas needed
How to improve Theiler staging?
In vitro dev’tputting cameraDifferentail gene expression analysis
Why is mouse good model organism (5 lang siguro)
Small mammal. It's a mammal. Short gestation period Enter puberty relatively early Large litter size Long reproductive lifespan Males do not harm pups Easy to handle Pregnancies are easily timed from insemination Placentation and early development are similar to humans Widely studied genetics
Complete cleavage of mouse
holoblastic, rotational
