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Lab Animal > Mouse genetics and nomenclature > Flashcards

Mouse genetics and nomenclature Flashcards

1
Q

How many generations of sibling mating are required for an inbred strain?

A

at least 20, not completely inbred until 40

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2
Q

Outbred, random bred or hybrid strains are NOT genetically defined EXCEPT…

A

F1 hybrids of 2 inbred strains

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3
Q

3 major disadvantages of inbred strains

A

represents only 1 genotype, homozygousity of deleterious alleles leading to poor fecundity and sensitivity to environmental conditions, slective breeding for the laboratory condition

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4
Q

Major advantages of an inbred strain

A

Defined experimental model, repeatable experimental results, reduce animal usage, opportunity to map and modify genes

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5
Q

mating scheme between two different strains or same inbred strains differing at a locus of interest is called ?

A

an outcross

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6
Q

heterozygote X heterozygote mating scheme is termed ?

A

an intercross

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7
Q

heterozygote X homozygote mating scheme, eg

Heterozygote offspring mated back to homozygous parental strain (not usually the parent itself) is called?

A

Backcross

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8
Q

homozygote X homozygote mating scheme(eg sibling mating) is termed?

A

An incross

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9
Q

Offspring of an outcross are denoted by what letter?

A

F1, F2, etc

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10
Q

Offspring of an intercross are denoted by what letter?

A

F

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11
Q

Offspring of a backcross are denoted by what letter?

A

N2, N3, etc (NO N1)

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12
Q

A mutant that differs at only single locus from original strain is called ?

A

coisogenic

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13
Q

A strain that differs from the original strain by a chromosomal segment is called ?

A

congenic

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14
Q

How is a congenic mouse derived?

A

Derived by repeated backcrossing mice carrying region of interest to parental strain

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15
Q

What is speed congenics?

A

techniques using simple sequence length polymorphism (SSLP) or SNP markers to cut the development time of congenic strain in half

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16
Q

A strain with a single, full-length chromosome from donor strain transferred to host strain by at least 10 backcrossings is called ?

17
Q

A congenic variation where donor genetic material is whole mitochondrial genome is called ?

A

Conplastic

18
Q

To create a conplastic strain at least 10 backcrosses of (males or females) from donor strain to recipient (males or females)

A

Female donor strain, male recipient strain

19
Q

A strain made by crossing two inbred strains then sibling inbreeding for >20 generations is called ?

A

Recombinant inbred

20
Q

A strain created from 2 distinct inbred strains to eventually result in a strain containing unequal genetic contributions is called ?

A

Recombinant congenic

21
Q

A strain that contains a foreign sequence of DNA stably inserted into genome through molecular manipulation is called ?

A

Transgenic

22
Q

A transgenic founder is always ___zygous for the transgene

A

Hemizygous

23
Q

Name 2 sources of genetic variability in inbred strains.

A

Contamination, genetic drift

24
Q

Substrains occur when colonies are separated by how many generations?

25
Q

What is the significance of the colon in the following mouse designation?
Crl:NMRI

A

Designates an outbred stock

26
Q

What is the significance of “db” in the following mouse strain designation?
C57BL/6J-db

A

db is the gene of interest in this coisogenic strain

27
Q

Is the following a coisogenic, congenic, consomic or conplastic strain?
C57BL/6J-tub

A

coisogenic

Strain-Gene symbol

28
Q

Is the following a coisogenic, congenic, consomic or conplastic strain?
B6.AKR-H2^k

A

congenic

Recipient strain. Donor strain -Gene symbol

29
Q

Is the following a coisogenic, congenic, consomic or conplastic strain?
B6.Cg-Kit^(W-44J)Gpi1^a

A

congenic

Recipient strain.Cg-Gene symbol

30
Q

Is the following a coisogenic, congenic, consomic or conplastic strain?
SHR-Chr Y^(BN)

A

Consomic

HOST STRAIN-Chr # ^(DONOR STRAIN)

31
Q

Is the following a coisogenic, congenic, consomic or conplastic strain?
C57BL/6J-mt^(BALB/c)

A

conplastic

NUCLEAR GENOME-mt^(CYTOPLASMIC GENOME)

32
Q

What is the significance of [cc] at the end of a strain name?

A

Closed colony

33
Q

A mutation in Foxn1 is associated with what common mouse model?

A

Nude mouse (Foxn1^nu)

34
Q

A mutation in Prkdc is associated with what common mouse model?

A

SCID mouse (Prkdc^scid)

35
Q

A mutation in Lyst is associated with what common mouse model?

A 
Beige mouse (Lyst^bg)
Chediak Higashi Syndrome like syndrome
36
Q

A mutation in Btk is associated with what common mouse model?

A

X linked immunodeficiency (Btk^xid)

Lab Animal (11 decks)

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