History and regulation

Question 1

True or false: Prior to 1920 rats were more commonly used than mice in biomedical research.

Answer 1

True

Question 2

In regards to DBA mice what does DBA stand for?

Answer 2

Dilute Brown non-Agouti

Question 3

The NIH intramural program was created as part of the _____ ______ Act.

Answer 3

Social Security Act, which allotted $2M for the study of rat sanitation

Question 4

True or false: Post WWII there was a decrease in independent campus animal programs in response to the surging economy.

Answer 4

False, explosive increase in independent campus animal programs

Question 5

Variablility in housing, food sources, caging, sanitation, ventilation/temperature, and animal care resulted in what 2 major drawbacks?

Answer 5

Animal health concerns Inability to repeat results

Question 6

In 1947, this code was adopted to define what constituted legitimate medical research in response to unethical scientific experimentation on human subjects.

Answer 6

Nuremburg Code (following the Nuremburg or Doctors’ Trial)

Question 7

In 1964, this document was adopted as the official policy document of the World Medical Association.

Answer 7

Declaration of Helsinki

Question 8

What are the last names of the “chicago Five” who founded the Animal Care Panel?

Answer 8

Brewer, Bond, Flynn, Cohen, SChroeder

Question 9

In 1953 this organization associated with National Academy of Sciences was formed.

Answer 9

Institute for Laboratory Animal Research

Question 10

What year was ACLAM formally established?

Answer 10

1957 (but not actually “ACLAM” until name change in 1961)

Question 11

Which lab animal organization puts out “The Guide”?

Answer 11

ILAR

Question 12

The Animal Care Panel become what organization in 1967?

Answer 12

AALAS

Question 13

What law first declared that care for laboratory animals must be provided under the care of a veterinarian?

Answer 13

Laboratory Animal Welfare Act

Question 14

The Aimal Welfare Act does not cover which species?

Answer 14

Mice, rats, birds

Question 15

Who is Peter Singer?

Answer 15

Author of “Animal Liberation” and Animal Rights movement founder in the US

Question 16

What significant and sometimes conficting regulation changes (law/policy passages and amendments) occurred in 1985?

Answer 16

Guide revised US Govt Principles for Utilization & Care of Vertebrate Animals in Testing, Research, and Training (IRAC) Policy on the HUmane Care and Use of Lab Animals (OPRR- OLAW) Congress passed the Health Research Extension Act (Public Law 99-158) AWA amended (Public Law 99-198)

Question 17

What is the title of the person with ultimate responsibility for animal care and use compliance?

Answer 17

Instution Official

Question 18

A momorandum of understanding exists between what 3 US institutions?

Answer 18

FDA, NIH, APHIS

Question 19

Name this person

Answer 19

Dr Nathan Brewer

Question 20

______ _______ refers to the scientific study of animals, usually in the laboratory, for the purpose of gaining new biomedical knowledge or solving specific medical, veterinary, dental, or biological problems.

Answer 20

Animal experimentation

Question 21

______ ______ _____ is the application of veterinary medicine and animal science to the acquisition of laboratory animals and to their managment, nutrition, breeding, and diseases

Answer 21

Laboratory animal care

Question 22

____ ____ is the study of the nature, cause and cure of abnormal structure and function in people, animals and plants for the eventual application to and benefit of all living things.

Answer 22

Comparative medicine

Question 23

_____ _____ ____ is the body of scientific and technicial information, knowledge, and skills that bears on both lab animal care and medicine

Answer 23

Laboratory animal science

Question 24

Living in 304-250 BC this person was likely the first to perform experiments on living animals and established that the trachea and lungs were pneumatic organs

Answer 24

Erasistratus