Mice Intro Flashcards
Are rats of the genus Rattus and mice of the genus Mus bred for use in research covered by USDA regulation
No
Are rats of the genus Rattus and mice of the genus Mus bred for use in research covered by PHS policy
Yes
Do mice have a gallbaldder
Yes (unlike rats)
The red staining around a mouse’s mouth and nose is due to the accumulation of _____ produced by the _______ gland, a lacrimal gland
accumulation of porphyrins produced by the Harderian gland
A mouse in a recent shipment of animals appears dehydrated and you want to give SQ fluids. What is the max volume you can give to an average size mouse?
2-3 ml, up to 0.5 ml/site
Continent of origin for the lab mouse?
Asia (Old World)
The laboratory mouse genome is a mixture of what 2 species?
M. musculus and M. domesticus
What is the difference between axenic, gnotobiotic, SPF, and conventional mice?
Axenic- germ free
Gnotobiotic- only defined GI flora, no other bacteria
SPF- specific pathogen free, but normal commensal flora
Conventional- microbes not defined, can have pathogenic organisms
What is the origin of the C3H strain?
From a cross of a Bagg albino female and a DBA male by Strong in 1920.
What is the color of C3H mice?
Agouti
Typical adult mouse weight
20-40 grams
Daily water consumption (ml/d) for a mouse?
6-7 ml/day
Daily food consumption (g/d) for a mouse?
4-5 g/day
Unique traits of murine urine include?
Urine is highly concentrated with large amounts of protein (0.5-1.0 ml in 24 hours)
Diploid chromosome number of the lab mouse? (2n= ?)
40
Age of puberty for mice?
Puberty ~ 35 days (range 28-49 days)
Mice are polyestrous and cycle every ___ days
4-5
What is the significance of a vaginal plug in mice?
Denatured seminal fluid and sperm that signifies copulation has occurred.
80-90% of mice with vaginal plugs become pregnant
When does the first post partum estrus occur?
12-24 hours after parturition
When does the post-lactation estrus occur?
2-4 days post weaning