BB Mouse Biology Flashcards
Most classical laboratory strains of mice are derived from what two wild mouse species?
Mus musculus musculus (E Euro)
M. m. domesticus (W Euro)
Mice have how many chromosomes?
40
Where in the mouse genome is the major histocompatibility complex (H2) located?
Ch 17
Subline variation makes nomenclature important. Which CBA subline has the gene for retinal degeneration, CBA/J or CBA/CaJ?
CBA/J
What organization maintains the central registry of Laboratory Registration Codes?
ILAR
What is the approximate daily food intake of an adult mouse (in g)?
3-5 g
What is the approximate daily water intake of mice (in mL)?
6-7 mL
What is the thermal neutral zone for mice?
29.6-30.5 C
or 85.3-86.9 F
How many lobes does a mouse have in the left lung?
Single left lung lobe
How many lobes does a mouse have in the right lung?
4- superior, middle, inferior, and post caval
Kidneys are larger in mice of which sex?
Male mice
Typically involution of the thymus in mice happens at what age?
Between 35-80 days
How many pairs of mammary glands do mice have?
5 pr, 3 cervicothoracic and 2 inguinoabdominal
Mating, estrus, and ovulation typically occur during what phase of the photoperiod in mice?
dark phase of photoperiod
Gestation length in mice?
19-21 days
What are the 4 subtypes of IgG in mice?
1, 2a, 2b, and 3
IgG1 is dominant in what type infection?
Parasitic
IgG2a is dominant in what types infections?
Viral or intracellular bacterial
IgG2b is induced by what?
T cell dependent antigens like carbohydrates
IgG3 is induced by what?
Bacterial antigens and T cell dependent antigens like carbohydrates
This immunodeficient mouse has a defect in Bruton’s tyrosine kinase resulting in few/impaired B cells
XID (model for human X-linked gammaglobulinemia)
This immunodeficient mouse is a model for Chediak Higashi syndrome
Beige mouse
This immunodeficient mouse has a phenotype which includes an absence of cytotoxic T cells and NK cells, folliculitis, and hypergammaglobulinemia
Moth-eaten mouse
