BB Mouse Biology

Question 1

Most classical laboratory strains of mice are derived from what two wild mouse species?

Answer 1

Mus musculus musculus (E Euro)

M. m. domesticus (W Euro)

Question 2

Mice have how many chromosomes?

Answer 2

40

Question 3

Where in the mouse genome is the major histocompatibility complex (H2) located?

Answer 3

Ch 17

Question 4

Subline variation makes nomenclature important. Which CBA subline has the gene for retinal degeneration, CBA/J or CBA/CaJ?

Answer 4

CBA/J

Question 5

What organization maintains the central registry of Laboratory Registration Codes?

Answer 5

ILAR

Question 6

What is the approximate daily food intake of an adult mouse (in g)?

Answer 6

3-5 g

Question 7

What is the approximate daily water intake of mice (in mL)?

Answer 7

6-7 mL

Question 8

What is the thermal neutral zone for mice?

Answer 8

29.6-30.5 C

or 85.3-86.9 F

Question 9

How many lobes does a mouse have in the left lung?

Answer 9

Single left lung lobe

Question 10

How many lobes does a mouse have in the right lung?

Answer 10

4- superior, middle, inferior, and post caval

Question 11

Kidneys are larger in mice of which sex?

Answer 11

Male mice

Question 12

Typically involution of the thymus in mice happens at what age?

Answer 12

Between 35-80 days

Question 13

How many pairs of mammary glands do mice have?

Answer 13

5 pr, 3 cervicothoracic and 2 inguinoabdominal

Question 14

Mating, estrus, and ovulation typically occur during what phase of the photoperiod in mice?

Answer 14

dark phase of photoperiod

Question 15

Gestation length in mice?

Answer 15

19-21 days

Question 16

What are the 4 subtypes of IgG in mice?

Answer 16

1, 2a, 2b, and 3

Question 17

IgG1 is dominant in what type infection?

Answer 17

Parasitic

Question 18

IgG2a is dominant in what types infections?

Answer 18

Viral or intracellular bacterial

Question 19

IgG2b is induced by what?

Answer 19

T cell dependent antigens like carbohydrates

Question 20

IgG3 is induced by what?

Answer 20

Bacterial antigens and T cell dependent antigens like carbohydrates

Question 21

This immunodeficient mouse has a defect in Bruton’s tyrosine kinase resulting in few/impaired B cells

Answer 21

XID (model for human X-linked gammaglobulinemia)

Question 22

This immunodeficient mouse is a model for Chediak Higashi syndrome

Answer 22

Beige mouse

Question 23

This immunodeficient mouse has a phenotype which includes an absence of cytotoxic T cells and NK cells, folliculitis, and hypergammaglobulinemia

Answer 23

Moth-eaten mouse