Motivation Control System Flashcards
What are the challenges of studying addiction in human populations
history of past drug exposure is hard to know
ethical barriers
what are the challenges of studying addiction in animal models
do not recapitulate all aspects of SUD
endophenotypes of addiction must be studied
what is tolerance
REDUCED brain response following repeated drug exposure
what is sensitization
ENHANCED brain response following repeated drug exposure
what is dependence
altered brain function upon cessation of drug use
often opposite of drug effect
what is incentive theory
our behavior is directed by a desire for external rewards
what is hedonic impact
the pleasure we experience from an action
what is incentive salience
our actual motivation to obtain something we like
What is incentive sensitization theory
Model to explain drug craving as a manifestation of incentive salience which becomes stronger with repeated drug use
Wanting and Liking Theory
Pleasure (liking) associated with early drug use
Craving (wanting) associated with chronic drug use
what is hedonic homeostatic dysregulation
mood undergoes allostatic changes with repeated drug exposure; key brain structures undergo neuroadaption as the individual cycles through Preoccupation Anticipation, Binge Intoxication, and Withdrawal Negative Affect
what is the reward circuit of the brain
VTA, NAc, Amygdala, ventral pallidum, hippocampus, prefrontal cortex
VTA under GABAergic inhibition
what is the mesolimbic pathway
dopamine neurons send their axons from the VTA to the NAc
what is the learning and memory system of the motivation control system
hippocampus
amygdala
what is the motor output part of the motivation control system
cortex
