Morgan and some mendel Flashcards
Morgan experiments with ..
fruit flies, provided convincing evidence that chromosomes are the location of mendel’s heritable factors
The first solid evidence associating a specific gene with a specific chromosome came from:
Thomas Hunt Morgan, an embryologist
Characteristics the make fruit flies a convenient organism for genetic studies :
- They breed at a high rate
- a generation can e bred every two weeks
- they have only four pairs of chromosomes
Morgan noted wild type, or normal, phenotypes that were common in the fly population..
traits alternative to the wild type are called mutant phenotypes
in one experiment, he mated male flies with white eyes (mutant) with female flies with red eyes (wild type) the results were:
the F1 generation all had red eyes
the F2 generation showed the 3:1 read :white eye ratio but only males had white eyes
sex plinked genes exhibit unique patterns of inheritance
- in humans and some other animals, there is a chromosomal basis of sex determination
- in humans and other mammals, there are two varieties of sex chromosomes: a larger X chromosomes and a smaller Y chromosome
only the ends of the Y chromosome have regions that are …
homologous with the X chromosome
The SRY gene on the Y chromosome codes for the development of
testes
Females are
XX
Males are
XY
Each ovum contains and X chromosome, while a sperm may contain
either and X or a Y
Other animals than humans have different methods of …
sex determination
inheritance of sex-linked genes
the sex chromosomes have genes for many characters unrelated to sex
a gene located on either sex chromosome is called a
sex-linked gene
they follow specific patterns of inheritance
(in humans it usually refers to a gene on the larger x chromosome)
for a recessive sex-linked trait to be expressed
a female need two copies of the allele
a male needs only one copy of the allele
Linked genes tend to be inherited together because…
they are located near each other on the same chromosome
each chromosome has..
hundreds or thousand of genes
linked genes
genes located on the same chromosome that tend to be inherited together
Morgan did other experiments with fruit flies to see how linkage affects inheritance of two characters: he crossed flies that differed in traits of body colour and wing size. the results were:
colour and wing size are usually inherited together in specific combinations (parental phenotypes) he notes that these genes do not assort independently, and reasoned that they were on the same chromosome (but non parental phenotypes were also produced)
genetic recombination
the production of offspring with combinations of traits differing from either parent
the genetic finding of mendel and morgan relate to the …
chromosomal basis of recombination
Mendel observed that combinations of traits in some offspring differ from either parent.
Parental types:
offspring with a phenotype matching one of the parental phenotypes
offspring with nonparental phenotypes (new combination of traits):
recombinant types or recombinants
a 50% frequency of recombination is observed for :
any two genes on different chromosomes
genes can be linked, but the linkage was incomplete,
as evident from recombinant phenotypes
some process must sometimes break the physical connection between genes on the same chromosome
crossing over of homologous chromosomes
genetic map
an ordered list of the genetic loci along a particular chromosome
(the farther apart two genes are, the higher the probability that a crossover will occur between them and therefore the higher the recombination frequency)
linkage map
genetic map of a chromosome based on recombination frequencies
distances between genes can be expressed as :
map units; one map unit or centimorgan represent a 1% recombination frequency
genes that are far apart on the same chromosome can have a recombination frequency near ..
50%
such genes are physically linked, but genetically unlinked, and behave as if found on different chromosomes
Abnormal chromosome number:
nondisjunction
pairs of homologous chromosomes do not separate normally during meiosis
as a result, one gamete receives two of the same type of chromosome, and another gamete receives no copy
Aneuplodiy
results from the fertilization of gametes in which nondisjunction occurred (offspring with this condition have an abnormal number of a particular chromosome)
polyploidy
is a condition in which an organism has more than two complete sets of chromosomes
triploidy (3n) is three sets of chromosomes
common in plants but not animals
breakage of a chromosome can lead to four types of changes in chromosome structure:
deletion
duplication
inversion
translocation
deletion
removes a chromosomal segment
duplication
repeats a segment
inversion
reverses a segment within a chromosome
translocation
moves a segment from one chromosome to another