Mood Quizzes 1-4 Flashcards
Please indicate which of the following receptors signals through coupling to a Gq (check all that applies):
A. Alpha 1
B. Alpha 2
C. 5-HT1
D. 5-HT2
E. 5-HT3
A. Alpha 1
D. 5-HT2
Please indicate which of the following is true regarding the 5-HT pathways (check all that applies):
A. 5HT3 in the limbic system are involved in anxiety and panic
B. Slow-wave sleep regulation is mediated by the 5HT2 receptor
C. Appetite and eating behavior is mediated by the 5HT2 receptor
B. Slow-wave sleep regulation is mediated by the 5HT2 receptor
Please indicate which of the following is true for depression (check all that applies):
A. When depression returns before there is a full remission of symptoms or within several months following remission it is called recurrence
B. Anxious responder is a patient with reduction of depressed mood but continuing anhedonia, lack of motivation and interest, and cognitive slowing
C. When treatment of depression results in greater than 50% improvement in symptoms the patient is called to be in response
C. When treatment of depression results in greater than 50% improvement in symptoms the patient is called to be in response
Please indicate which of the following is true for MAO (check all that applies):
A. MAO inhibitors was originally discovered because of antidepressive “side effect” in patients treated for tuberculosis
B. MAO-B is a very selective isozyme of MAO for the destruction of norepinephrine and serotonin
C. Increased MAO-A activity was suggested to be linked to some types of treatment-resistant depression
A. MAO inhibitors was originally discovered because of antidepressive “side effect” in patients treated for tuberculosis
C. Increased MAO-A activity was suggested to be linked to some types of treatment-resistant depression
Please indicate which of the following is true for tricyclic antidepressants (check all that applies):
A. Tricyclic antidepressants cause weight gain due to the blockade of H1 histamine receptor
B. Tricyclic antidepressants was originally discovered because of the antidepressive “side effect” in patients treated for schizophrenia
C. Tricyclic antidepressants is the older name for SSRI
A. Tricyclic antidepressants cause weight gain due to the blockade of H1 histamine receptor
B. Tricyclic antidepressants was originally discovered because of the antidepressive “side effect” in patients treated for schizophrenia
Please indicate which of the following is true for alpha 1 subtype adrenergic receptors (check all that applies):
A. Located of serotonergic terminals
B. Located in the sympathetic system where it controls urinary retention
C. signal via stimulation of adenylyl cyclase
B. Located in the sympathetic system where it controls urinary retention
Please indicate which of the following is true for NE-serotonin interaction (check all that applies):
A. Terminal adrenergic heteroreceptors inhibit adenylyl cyclase activity and cause decrease in serotonin release
B. Alpha 2 receptors are located on serotonergic neurons in the raphe nucleus, where it is inhibiting serotonin release
C. The norepinephrine system in the brainstem acts to accelerate serotonin release
A. Terminal adrenergic heteroreceptors inhibit adenylyl cyclase activity and cause decrease in serotonin release
C. The norepinephrine system in the brainstem acts to accelerate serotonin release
The sedating effect of tricyclic antidepressants is because of their blockade of which of the following receptors (check all that applies):
A. Alpha 1
B. Histamine receptor
C. Cholinergic receptor
B. Histamine receptor
C. Cholinergic receptor
Which of this(these) SSRI(s) is(are) more activating, energizing, and thus preferred for fatigue-reducing symptoms:
A. Fluoxetine
B. Escitalopram
C. Paroxetine
A. Fluoxetine
Which of the following is not a symptoms of norepinephrine deficiency syndrome:
A. Fatigue
B. Slowness of information processing
C. Obsession and compulsion
D. Problem concentrating
C. Obsession and compulsion
Please indicate which of the following is true for the monoamine hypothesis: (check all that applies):
A. Depression is caused by absence of key monoamine receptors in the brain
B. Depression is caused by deficiency of monoamines
C. Depression is caused by a problem in monoamine activating critical neuronal gene
B. Depression is caused by deficiency of monoamines
Please indicate which of the following is true for the monoamine receptor hypothesis: (check all that applies):
A. The monoamine receptor hypothesis of depression suggest that depression is caused by an absence of a key monoamine receptor in the brain
B. According to the monoamine receptor hypothesis, the mechanism of therapeutic action of the SSRI is down-regulation of the somatodendritic 5-HT1A autoreceptors
C. The monoamine receptor hypothesis is supported by the fact the elevation of serotonin levels by SSRIs first observed in the raphe nucleus and later on in the cortex
B. According to the monoamine receptor hypothesis, the mechanism of therapeutic action of the SSRI is down-regulation of the somatodendritic 5-HT1A autoreceptors
C. The monoamine receptor hypothesis is supported by the fact the elevation of serotonin levels by SSRIs first observed in the raphe nucleus and later on in the cortex
Increase monoamine levels in the raphe nuclei results in (check all that applies):
A. Desensitization of the 5HT1A receptors
B. Sensitization of the 5HT1A receptors
C. Down regulation of the 5HT1A receptors
D. Up regulation of the 5HT1A receptors
A. Desensitization of the 5HT1A receptors
C. Down regulation of the 5HT1A receptors
Which of the following drug mechanism include 5HT1A partial agonism (check all that applies):
A. SPARI
B. SARI
C. SNRI
D. NaSSA
A. SPARI
Which of the following drugs block monoamine reuptake (check all that applies):
A. SPARI
B. SARI
C. SNRI
D. NaSSA
A. SPARI
B. SARI
C. SNRI
