Glutamate In SZ Flashcards
Hyperactivity in the Mesolimbic pathway leads to what diagnosis?
Schizophrenia
What type of schizophrenia symptoms does hyperactivity of the mesolimbic pathway cause?
Positive
Hypoactivity in the mesocortical pathway causes what type of symptoms?
Negative
Hypoactivity in the ventromedial PFC has what effect on social function?
Lack in social functions
What causes auditory hallucinations in schizophrenia?
NMDA hypofunction -> neurons downstream to be hyperactive -> mesolimbic path to have too much activation -> auditor6 hallucination
What it he Thalamus theory?
DA and glutamate in thalamus filter doesn’t work well and leads to schizophrenia
In the thalamus theory, what is the filter balanced by?
The levels of DA and glutamate
What are examples of Conventional Antipsychotics?
D2 Antagonists and Neuroleptics
What dopaminergic pathway does neuroleptic-induced deficit syndrome affect? What affect does it have on negative symptoms?
The mesocortical pathway; increase in negative symptoms
blocking the DA in the extrapyramidal system affects the (direct/indirect) pathway
Indirect
Drug-induced Parkinsonism is also known as:
Extrapyramidal symptoms (EPS)
What is tardive dyskinesia caused by?
Upregulation of the D2 receptor (too much blockage occurs)
What pathway connects the population of dopamine neurons in the arcuate nucleus of the mediobasal hypothalamus to the median eminence?
the tuberoinfundibulnar pathway
Which pathway is involved in hyperprolactinemia?
The tuberoinfundibulnar pathway
What three things are associated with hyperprolactinemia?
- galactorrhea
- amenorrhea
- sexual dysfunction
