Antidepressants And Mood stabilizers Flashcards
A more pure treatment leads to more people that are treatment resistant. Why is this?
It could be due to getting rid of some elements in the drug
What is a SPARI?
Serotonin partial agonist/reuptake inhibitors
SPARI is a 5HT____ is a partial agonist
1A
Are SNRIs used to treat depression in the US?
No
what is the dopamine receptor hypothesis?
- 5HT1A receptor is unregulated -> shutting off 5HT release
- down regulation in raphe nucleus -> release of 5HT in target
- delay we see with SSRI is because receptor is low activity
True or False: When a NE transporter sees DA, it also uptakes DA
True
When you inhibit NE reuptake, NE and DA concentration (increase/decrease) in the PFC
Increase
What is the effect of increased DA in the limbic areas?
It is problematic and abusive
Where to NRIs increase DA?
In the PFC (but not the limbic areas)
alpha ____ antagonists increase release of NE and serotonin
2
What is HHT2A coupled to?
Gq
What is 5HT2C coupled to?
Gq
what does NaSSA stand for?
Noradrenergic and specific serotonergic antidepressant
what is a very efficient antidepressant that deals with the circadian rhythm?
Agomelatine
What drug is a MT1/MT2 agonist and 5HT2C antagonist that enhances neurogenesis/BDNF?
Agomelatine
