Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Biology Of Psychologal Disorders > 5HT And NE > Flashcards

5HT And NE Flashcards

1
Q

What are the two types of monoamines?

A

Indolamines and catecholamines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Out of dopamine, norepinephrine, epinephrine, and serotonin, which of the above are indolamines?

A

Serotonin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the rate limiting enzyme on the path from L-tyrosine to Epinephrine?

A

Tyrosine hydroxylase (TH)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the enzymes that inactivate catecholamines?

A

MAO and COMT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is MAO-A selective for?

A

NE and serotonin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is MAO-B for?

A

It acts on dopamine and broad spectrum of phenylethylamines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Norepinephrine deficiency syndrome common symptoms:

A
  • impaired attention
  • depressed mood
  • psychomotor retrardation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Serotonin containing neuronal cell bodies are mainly restricted to discrete clusters of cells located along the midline of the brain stem - _________

A

The raphe nuclei

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

5-HT 1A is located where? what does it cause?

A

Somatodendritic auto receptors and postsynaptic ; decrease in firing and decrease in 5HT release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

5-HT 1D is located where? What does it do?

A

Terminal auto receptors ; inhibit release of neurotransmitters

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the serotonin receptors for mood?

A

Postsynaptic beta 1 receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the function of 5HT 2A?

A
  • stimulation of phospholipase C
  • closing of K+ channels
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What serotonin receptors are involved in anxiety and panic?

A

5HT-2A and 5HT-2C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What serotonin receptors are involved in appetite and eating behavior?

A

5HT-3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What serotonin receptors are involved in appetite and GI motility?

A

5HT-3 and 5HT-4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What serotonin receptor is involved in sleep?

A

5HT-2A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What serotonin receptor is involved in the vomit center?

A

5HT-3

18
Q

What are the symptoms of serotonin deficiency syndrome?

A
  • depressed mood
  • anxiety
  • panic
    -phobia
  • anxiety
  • obsessions and compulsions
  • food craving; bulimia
19
Q

What happens when the alpha 2 hetero receptor is activated on the serotonin neuron?

A

It inhibits 5HT and NE

20
Q

What is the alpha 1 receptor coupled to?

A

Gq

21
Q

Alpha 1 ______ 5HT production while alpha 2 ______ it

A

Increases; inhibits

22
Q

What was the original purpose for MAO inhibitors?

A

To treat tuberculosis

23
Q

What was the first drug discovered to treat depression?

A

MAO inhibitors

24
Q

the original MAO inhibitors were __________ and ___________

A

Non-selective and irreversible

25
Q

What kind of MAO inhibitors are irreversible and nonselective?

A

Classical MAO inhibitors

26
Q

What are RIMAs?

A

Reversible inhibitors of MAO A (and they aren’t very effective)

27
Q

True or False: selective inhibitors of MAO B are used for depression

A

False

28
Q

What happens to the level of dopamine when MAO-B is inhibited?

A

It is elevated

29
Q

Increased MAO-___ is thought to be linked with some types of treatment-resistant depression and vulnerability to relapse

A

A

30
Q

What kind of MAO inhibitors do you use to treat treatment-resistant depression?

A

MAO-A

31
Q

What were tricyclic antidepressants originally used to try to treat?

A

Psychosis

32
Q

What does NRI stand for?

A

Norepinephrine reuptake inhibition

33
Q

what is the tricyclic antidepressant M1 receptor associated with?

A

Dry mouth drowsiness

34
Q

What is the H1 receptor associated with?

A

Weight gain

35
Q

What is the tricyclic alpha receptor associated with?

A

Dizziness and decreased blood pressure

36
Q

What are the two reasons why SSRIs work differently between people?

A
  • pharmacodynamics
  • pharmacokinetics
37
Q

Fluoxetine is a 5HT2C ________ that causes release of NE and DA

A

Antagonist

38
Q

Monoamine hypothesis

A

The reason why have depression is because we have a lack of monoamines. If we were to raise the monoamine levels, depression would be cured.

39
Q

Is the monoamine hypothesis accurate?

A

No it is an incorrect theory

40
Q

In the raphe nucleus, the increase of 5-HT causes a ______________ of the auoreceptors. This releases the inhibition on serotonin release in the terminals.

A

Down-regulation

41
Q

what happens when there is an increase of 5-HT at the terminals?

A

Effect on mood. This will case down-regulation of the postsynaptic receptors

Biology Of Psychologal Disorders (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions